规格

价格

库存

数量

1 mg

¥ 213

5日内发货

5 mg

¥ 468

5日内发货

10 mg

¥ 680

5日内发货

25 mg

¥ 1,120

5日内发货

50 mg

¥ 1,660

5日内发货

100 mg

¥ 2,470

5日内发货

200 mg

¥ 3,680

5日内发货

生物活性

产品描述	7-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) shows IC50 values of 0.085 nM, against HeLa cells.
体外活性	7-Epi-10-deacetyltaxol(EDT)在体外对HepG2细胞显示出显著的细胞毒性。用真菌EDT处理的细胞中观察到核凝聚和DNA碎片化。此外，真菌EDT使HepG2细胞在细胞周期的G2/M阶段停滞。进一步地，真菌EDT以剂量依赖的方式诱导HepG2细胞凋亡，这与ROS的生成、Bax/Bcl-2比值的增加、p38 MAPKs和PARP裂解有关[1]。
细胞实验	The endophytic fungus was identified by traditional and molecular taxonomical characterization and the fungal 7-Epi-10-deacetyltaxol(EDT) was purified using column chromatography and confirmed by various spectroscopic and chromatographic comparisons with authentic paclitaxel.?Studied the in vitro effects of EDT on HepG2 cells for parameters such as cell cycle distribution, DNA fragmentation, reactive oxygen species (ROS) generation and nuclear morphology.?Further, western blot analysis was used to evaluate Bcl-2-associated X protein (Bax), B-cell lymphoma 2 (Bcl-2), p38-mitogen activated protein kinase (MAPK) and poly [ADP-ribose] polymerase (PARP) expression[1].
别名	7-表-10-去乙酰基云南紫杉宁A, 7-Epi-10-deacetyltaxol, 10-Deacetyl-7-epipaclitaxel

化学信息

分子量	811.87
分子式	C₄₅H₄₉NO₁₃
CAS No.	78454-17-8
Smiles	[H][C@@]12C[C@@H](O)[C@@]3(C)C(=O)[C@H](O)C4=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c5ccccc5)[C@]3([H])[C@@]1(CO2)OC(C)=O)C4(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)c1ccccc1)c1ccccc1
密度	1.41 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 100 mg/mL (123.17 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.23 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2317 mL	6.1586 mL	12.3172 mL	61.5862 mL
5 mM	0.2463 mL	1.2317 mL	2.4634 mL	12.3172 mL
10 mM	0.1232 mL	0.6159 mL	1.2317 mL	6.1586 mL
20 mM	0.0616 mL	0.3079 mL	0.6159 mL	3.0793 mL
50 mM	0.0246 mL	0.1232 mL	0.2463 mL	1.2317 mL
100 mM	0.0123 mL	0.0616 mL	0.1232 mL	0.6159 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

7-Epi 10-desacetyl paclitaxel

7-Epi 10-desacetyl paclitaxel

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词

7-Epi 10-desacetyl paclitaxel

7-Epi 10-desacetyl paclitaxel