Dextromilnacipran

Name: Dextromilnacipran
Brand: TargetMol
SKU: T2594
Price: 198 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.5%

货号 T2594Cas号 96847-55-1

别名 左旋米那普仑, Levomilnacipran

Dextromilnacipran (Levomilnacipran) 是米那普仑的对映体，是一种选择性 5- 羟色胺和去甲肾上腺素(5-HT/NE)再摄取抑制剂，也是一种人类 α 肾上腺素能受体拮抗剂，IC50=3.4 μM。

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Dextromilnacipran

一键复制产品信息

很棒

纯度: 99.5%

货号 T2594 别名 左旋米那普仑, LevomilnacipranCas号 96847-55-1

规格	价格	库存
1 mg	¥ 198	现货
5 mg	¥ 448	现货
10 mg	¥ 776	现货
25 mg	¥ 1,550	现货
50 mg	¥ 2,290	现货
100 mg	¥ 3,430	现货
500 mg	¥ 7,470	现货
1 mL x 10 mM (in DMSO)	¥ 565	现货

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纯度: 99.5%

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产品介绍

Dextromilnacipran AI Summary

**Dextromilnacipran** is a pharmacologically active compound primarily studied for its interactions with neurotransmitter transporters, demonstrating significant inhibition of the norepinephrine transporter (NET) and moderate inhibition of the serotonin transporter (SERT). It exhibits potent inhibition of human NET with an IC50 as low as 77.0 nM and moderate inhibition of human SERT with IC50 values ranging between 100.0 nM and 420.0 nM across different studies. The compound shows weaker inhibition of the dopamine transporter (DAT) with an IC50 of 6100.0 nM. Pharmacokinetically, Dextromilnacipran has high oral bioavailability in humans at 84%, with a rapid Tmax of 2.0 hours and a moderate half-life of 8.0 hours. It demonstrates moderate protein binding in human plasma (13.0%) and significant excretion activity in human urine (>80.0%). The compound shows metabolic stability in both human and rat liver microsomes, with clearance values of 3.1 mL.min-1.kg-1 and 24.0 mL.min-1.kg-1 respectively, and exhibits low affinity for P-glycoprotein-mediated transport. Additionally, it has a Log D value of 0.2, indicating moderate lipophilicity, and shows favorable permeability in Caco-2 cell lines. Despite its effective bioactivity, Dextromilnacipran exhibits moderate liver toxicity, indicated by a severity class index of 7.0 for drug-induced liver injury, and shows potential hepatotoxic effects without significant chronic liver disease or tumor formation. Overall, Dextromilnacipran holds promise for modulating neurotransmitter transporters, especially NET and SERT, with potential therapeutic implications and significant pharmacokinetic and pharmacodynamic profiles that warrant further investigation..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Dextromilnacipran (Levomilnacipran) is a selective serotonin and norepinephrine reuptake inhibitor.
靶点活性	α-adrenoceptor:3.4 μM (IC50)
别名	左旋米那普仑, Levomilnacipran

化学信息

分子量	246.35
分子式	C₁₅H₂₂N₂O
CAS No.	96847-55-1
Smiles	C(N(CC)CC)(=O)[C@]1([C@@H](CN)C1)C2=CC=CC=C2
密度	1.077

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 250 mg/mL (1014.82 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0593 mL	20.2963 mL	40.5927 mL	202.9633 mL
5 mM	0.8119 mL	4.0593 mL	8.1185 mL	40.5927 mL
10 mM	0.4059 mL	2.0296 mL	4.0593 mL	20.2963 mL
20 mM	0.2030 mL	1.0148 mL	2.0296 mL	10.1482 mL
50 mM	0.0812 mL	0.4059 mL	0.8119 mL	4.0593 mL
100 mM	0.0406 mL	0.2030 mL	0.4059 mL	2.0296 mL