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2-Bromo-4'-hydroxyacetophenone
很棒
产品编号 T7084Cas号 2491-38-5
别名 α-Bromo-4-hydroxyacetophenone, SHP-1 Inhibitor II, PTP Inhibitor I, 4-Hydroxyphenacyl bromide, 2-溴-4'-羟基苯乙酮
2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) 是一种PTP1B 的有效抑制剂，其Ki=42 μM。
2-Bromo-4'-hydroxyacetophenone
很棒 纯度: 98.64%
产品编号 T7084 别名 α-Bromo-4-hydroxyacetophenone, SHP-1 Inhibitor II, PTP Inhibitor I, 4-Hydroxyphenacyl bromide, 2-溴-4'-羟基苯乙酮Cas号 2491-38-5
2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) 是一种PTP1B 的有效抑制剂，其Ki=42 μM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 500 mg | ¥ 136 | 现货 | |
| 1 g | ¥ 188 | 现货 |
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客户已引用产品介绍
生物活性
化学信息
| 产品描述 | 2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)) with a Ki value of 43 μM and PTP1B with a Ki value of 42 μM [1]. SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research [2]. |
| 靶点活性 | SHP1:43 μM (Ki, cell free), PTP1B:42 μM (Ki, cell free) |
| 细胞实验 | Cell lines: human B cells. Concentrations: 30, 100, 300, 1000 μM. Method: After incubation with varying concentrations of PTP Inhibitor I for 3 min, the cells are lysed, and the cellular proteins are separated on an SDS-PAGE gel, followed by western blot analysis. |
| 别名 | α-Bromo-4-hydroxyacetophenone, SHP-1 Inhibitor II, PTP Inhibitor I, 4-Hydroxyphenacyl bromide, 2-溴-4'-羟基苯乙酮 |
| 分子量 | 215.04 |
| 分子式 | C8H7BrO2 |
| CAS No. | 2491-38-5 |
| Smiles | OC1=CC=C(C=C1)C(=O)CBr |
| 密度 | 1.622 g/cm3 (Predicted) |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| 溶解度信息 | Ethanol: 20 mg/mL (93.01 mM), Sonication is recommended. H2O: Insoluble DMSO: 60 mg/mL (279.02 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 一共给药动物 10 只 ，您使用的配方为 5% 
DMSO+ 30%PEG300+ 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为 2 mg/mL 。 体内配方的制备方法: 取 50μLDMSO 母液，添加 300 μLPEG300 混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLSaline/PBS/ddH2O 混匀澄清
母液，添加 300 μLPEG300 混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLSaline/PBS/ddH2O 混匀澄清 以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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