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FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone) 是一种氧化磷酸化 (OXPHOS) 抑制剂,线粒体质子载体解偶联剂。FCCP 常被用作细胞凋亡诱导剂。
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FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone) 是一种氧化磷酸化 (OXPHOS) 抑制剂,线粒体质子载体解偶联剂。FCCP 常被用作细胞凋亡诱导剂。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | ¥ 283 | In stock | |
10 mg | ¥ 425 | In stock | |
25 mg | ¥ 862 | In stock | |
50 mg | ¥ 1,690 | In stock | |
100 mg | ¥ 2,860 | In stock | |
200 mg | ¥ 4,220 | In stock | |
500 mg | ¥ 6,590 | In stock | |
1 mL x 10 mM (in DMSO) | ¥ 298 | In stock |
FCCP 相关产品
产品描述 | FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. FCCP is often used as an apoptosis inducer. |
靶点活性 | mitoCHO cellsndrial oxidative pHOS cellsphate:20 nM, T47D cells:0.31 μM |
体外活性 | 方法:大鼠心室肌细胞用 FCCP (10-1000 nM) 处理 1400 sec,使用 Clark Oxygen Electrode 检测细胞耗氧量。 |
体内活性 | 方法:为检测对中风的影响,将 FCCP (1 mg/kg) 腹腔注射给中风的 C57BL/6J 小鼠模型,然后进行一小时的短暂性大脑中动脉闭塞 (tMCAO)。 |
细胞实验 | Protein synthesis rate is assayed in 24-mm diameter multi-well dishes with fresh medium containing 0.175 Ci/mmol of [3H]methionine (200 μM), for 30 min at 37°C. PC12 cells are treated with FCCP for different period of times. (Only for Reference) |
别名 | Trifluoromethoxy carbonylcyanide phenylhydrazone, Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone |
分子量 | 254.17 |
分子式 | C10H5F3N4O |
CAS No. | 370-86-5 |
Smiles | FC(F)(F)Oc1ccc(NN=C(C#N)C#N)cc1 |
密度 | 1.34 g/cm3 |
存储 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 55 mg/mL (216.39 mM), Sonication is recommended. ![]() | |||||||||||||||||||||||||||||||||||
体内实验配方 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.54 mg/mL (9.99 mM), Solution. 请按顺序添加溶剂,在添加下一种溶剂之前,尽可能使溶液澄清。如有必要,可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考,体内配方并不是绝对的,请根据不同情况进行调整。![]() | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。
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