Name: Posaconazole hydrate
Brand: TargetMol
SKU: T23174
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

¥ 10,600

1-2周

50 mg

¥ 13,800

1-2周

100 mg

¥ 17,500

1-2周

生物活性

产品描述	Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity. Posaconazole is a sterol C14ɑ demethylase inhibitor (IC50: 0.25 nM). Posaconazole strongly inhibits 14-alpha demethylase, a cytochrome P450-dependent enzyme.
体外活性	Inhibition of 14-alpha-demethylase prevents the conversion of lanosterol to ergosterol, an important component of the fungal cell wall. Inhibition of ergosterol synthesis changes the fungal cell membrane composition and integrity, alters membrane permeability, and eventually leads to fungal cell lysis. Compared to other azole antifungals, posaconazole is a significantly more potent inhibitor of sterol 14-alpha demethylase. Posaconazole is the most advanced candidate for the treatment of Chagas disease. Posaconazole has entered in phase II clinical trial in the treatment of mycoses.
别名	泊沙康唑水合物

化学信息

分子量	718.79
分子式	C₃₇H₄₄F₂N₈O₅
CAS No.	1198769-38-8
Smiles	C([C@@]1(C[C@H](COC2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)N5C(=O)N([C@H]([C@H](C)O)CC)N=C5)CO1)C6=C(F)C=C(F)C=C6)N7C=NC=N7.O
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: Soluble

Posaconazole hydrate