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Chelerythrine
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很棒纯度: 99.96%
货号 T6S0052Cas号 34316-15-9
别名 白屈菜红碱, Toddalin, Cheleritrine, Broussonpapyrine
Chelerythrine (Broussonpapyrine) 是一种天然生物碱，为有效、选择性的 Ca2+/磷脂依赖性PKC 拮抗剂，IC50值为 0.7 μM。它具有抗肿瘤、抗糖尿病、抗炎的活性。它抑制BclXL-Bak BH3肽结合，IC50为 1.5 μM，并从 BclXL 取代了 Bax。它诱导细胞凋亡和自噬。
其他形式的 “Chelerythrine”:
Chelerythrine
一键复制产品信息 很棒纯度: 99.96%
货号 T6S0052 别名 白屈菜红碱, Toddalin, Cheleritrine, BroussonpapyrineCas号 34316-15-9
Chelerythrine (Broussonpapyrine) 是一种天然生物碱，为有效、选择性的 Ca2+/磷脂依赖性PKC 拮抗剂，IC50值为 0.7 μM。它具有抗肿瘤、抗糖尿病、抗炎的活性。它抑制BclXL-Bak BH3肽结合，IC50为 1.5 μM，并从 BclXL 取代了 Bax。它诱导细胞凋亡和自噬。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 5 mg | ¥ 417 | 现货 | |
| 10 mg | ¥ 777 | 现货 | |
| 25 mg | ¥ 1,297 | 现货 | |
| 50 mg | ¥ 1,948 | 现货 | |
| 100 mg | ¥ 2,923 | 现货 | |
| 1 mL x 10 mM (in DMSO) | ¥ 467 | 现货 |
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产品介绍
Chelerythrine AI Summary
Chelerythrine exhibits a broad spectrum of bioactivities across diverse biochemical pathways and functions. It acts as an agonist for the NFkB Signaling Pathway (potency of 11220.2 nM) and the Thyroid Stimulating Hormone Receptor (potency of 25118.9 nM), as well as a potent inhibitor of various targets including HSD17B4 (25118.9 nM), Tyrosyl-DNA Phosphodiesterase (TDP1) (63095.7 nM), human liver OATP2B1 (13.1% inhibition), and recombinant human DOPA decarboxylase enzyme (IC50 of 1280000.0 nM). It inhibits mitochondrial division or activates mitochondrial fusion (5804.8 nM) and enhances SMN2 Splice Variant Expression (7079.5 nM). Notably, Chelerythrine shows strong binding affinity to c-myc and c-Kit1 G-quadruplex DNA, demonstrating significant antiproliferative activity against several human cancer cell lines, with complete inhibition of viability at 20 uM concentration in MTT assays.
Additionally, Chelerythrine has pronounced antibacterial properties, effective against methicillin-resistant and methicillin-sensitive Staphylococcus aureus (MIC90 of 4.0 ug/mL), as well as vancomycin-resistant and vancomycin-sensitive Enterococcus faecalis (MIC90 of 32.0 ug/mL). It also inhibits Mycobacterium tuberculosis (MIC of 3.1 ug/mL). The compound displays competitive inhibition of human MAO-A (Ki of 220.0 nM) and MAO-B, favoring MAO-A with higher potency. It intervenes in cholinesterase activity, with IC50 values of 1450.0 nM for acetylcholinesterase (AChE) and 8580.0 nM for butyrylcholinesterase (BuChE), showing selectivity towards AChE.
Chelerythrine also demonstrates selective cytotoxicity across different cell lines, with the highest potency against LL24 cells and the least against A549 cells. It furthers its bioactivity by binding to the PPARgamma ligand-binding domain (IC50 of 566.0 nM) and inhibiting SERCA1a activity with varied potencies (1200.0 nM to 27000.0 nM). These diverse activities suggest that Chelerythrine may have potential therapeutic applications in cancer, bacterial infections, neurodegenerative diseases, and metabolic disorders..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | 1. Chelerythrine (Broussonpapyrine) may have antimanic effect . 2. Chelerythrine can inhibit telomerase activity. 3. Chelerythrine is a well-known protein kinase C inhibitor . 4. Chelerythrine has potential antiproliferative and antitumor effects. |
| 靶点活性 | PKC:0.7 μM (IC50) |
| 别名 | 白屈菜红碱, Toddalin, Cheleritrine, Broussonpapyrine |
| 分子量 | 348.37 |
| 分子式 | C21H18NO4 |
| CAS No. | 34316-15-9 |
| Smiles | C[N+]=1C=2C(C=3C(C1)=C(OC)C(OC)=CC3)=CC=C4C2C=C5C(=C4)OCO5 |
| 密度 | 1.2985 g/cm3 (Estimated) |
| 颜色 | Yellow |
| 物理性状 | Solid |
| 存储 | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| 溶解度信息 | DMSO: 11 mg/mL (31.58 mM), Sonication is recommended.  | |||||||||||||||||||||||||
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TCMIP相关数据
中药材来源及性味归经
所属中成药
| 中药材名称 | 中药材拉丁名 | 性 | 味 | 归经 |
|---|---|---|---|---|
| 两面针 | Zanthoxylum nitidum (Roxb.) DC. | 平 | 苦, 辛 | 肝, 胃 |
| 中成药名称 | 处方组成 | 中成药类型 |
|---|---|---|
| 宫炎平滴丸 | 地稔,两面针,当归,五指毛桃,穿破石 | 清热药 |
| 金花跌打酊 | 红花,龙血竭,香附,两面针,樟脑,千斤拔,木香,白木香,乳香,没药,莪术,牛膝,骨碎补,金不换,黄柏,黄连,三叉苦木,鸭脚木皮,榕树须,土鳖虫 | 活血化瘀药 |
| 鼻咽清毒剂 | 野菊花,苍耳子,重楼,蛇泡簕,两面针,夏枯草,龙胆,党参 | 清热药 |
| 复方风湿宁片 | 两面针,七叶莲,宽筋藤,过岗龙,威灵仙,鸡骨香 | 治风药 |
| 复方风湿宁注射液 | 两面针,七叶莲,宽筋藤,过岗龙,威灵仙,鸡骨香 | 祛风活络药 |
| 金鸡分散片 | 金樱根,鸡血藤,千斤拔,功劳木,两面针,穿心莲 | 清热药 |
| 复方风湿宁颗粒 | 两面针,七叶莲,宽筋藤,过岗龙,威灵仙,鸡骨香 | 治风药 |
| 复方风湿宁胶囊 | 两面针,七叶莲,宽筋藤,过岗龙,威灵仙,鸡骨香 | 治风药 |
| 活络止痛丸 | 鸡血藤,何首乌,过岗龙,牛大力,莶草,豆豉姜,半枫荷,两面针,臭屎茉莉,走马胎,威灵,连钱草,千斤拔,独活,穿破石,薏苡仁,土五加,钩藤,山白芷,宽筋藤 | 祛瘀药 |
| 华佗风痛宝胶囊 | 红鱼眼,九层风,三叶青藤,山风(或大风艾),两面针,三七茎叶 | 治风药 |
| 妇炎净片 | 苦玄参,地胆草,当归,鸡血藤,两面针,横经席,柿叶,菥蓂,五指毛桃 | 清热药 |
| 复方两面针漱齿液 | 厚朴,两面针,薄荷脑 | 清热药 |
| 妇炎净胶囊 | 苦玄参,地胆草,当归,鸡血藤,两面针,横经席,柿叶,菥蓂,五指毛桃 | 清热药 |
| 宫炎平分散片 | 地稔,两面针,当归,五指毛桃,穿破石 | 清热药 |
| 复方两面针含片 | 西青果,两面针,山豆根,薄荷 | 清热药 |
| 古威活络酊 | 细辛,徐长卿,七味莲,两面针,古羊藤,十八症,鸡骨香,搜山虎,救必,应,九龙藤,大血藤,山花椒,良姜,威灵仙,千斤拔,桂枝,白芷,五加皮,防已,木香,泽兰,土鳖虫,续断,独活,薄荷脑,樟脑 | 祛风活络药 |
| 金鸡丸 | 金樱根,鸡血藤,千斤拨,功劳木,两面针,穿心莲 | 清热药 |
| 宫炎平胶囊 | 地稔,五指毛桃,两面针,穿破石,当归 | 清热药 |
| 复方草玉梅含片 | 草玉梅,两面针,射干,百合,地黄,玄参,岗梅,甘草,薄荷脑,薄荷素油,磷酸氢钙,香兰素 | 清热药 |
| 蟾乌凝胶膏 | 蟾酥,生川乌,两面针,重楼,生关白附,芙蓉叶,三棱,莪术,红花,丁香,细辛,肉桂,六轴子,荜菝,甘松,山奈,乳香,没药,薄荷脑,冰片,樟脑 | 祛瘀药 |
计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， 一共给药动物10只，您使用的配方为5%
DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。 以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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