GNE-490

Name: GNE-490
Brand: TargetMol
SKU: T22339
Price: 598 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.77%

货号 T22339Cas号 1033739-92-2

GNE-490 是一种有效的 pan-PI3K 抑制剂，对 PI3Kα、PI3Kβ、PI3Kδ 和 PI3Kγ 的 IC50 分别为 3.5 nM、25 nM、5.2 nM、15 nM。 GNE-490 对 mTOR 具有 >200 倍的特异性（IC50 = 750 nM）。

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GNE-490

一键复制产品信息

很棒

纯度: 99.77%

货号 T22339Cas号 1033739-92-2

规格	价格	库存
1 mg	¥ 598	现货
2 mg	¥ 926	现货
5 mg	¥ 1,660	现货
10 mg	¥ 2,470	现货
25 mg	¥ 3,930	现货
50 mg	¥ 5,390	现货
100 mg	¥ 7,130	现货
200 mg	¥ 9,620	现货
1 mL x 10 mM (in DMSO)	¥ 1,750	现货

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产品介绍

GNE-490 AI Summary

GNE-490 exhibits multiple bioactivities including antiproliferative activity against human PC3 cells deficient in PTEN and MCF7.1 cells expressing PI3Kalpha mutant. It inhibits various kinases such as PI3K isoforms (alpha, beta, gamma, delta), mTOR, and PIK3C2beta. Additionally, it significantly inhibits the PI3K/Akt/mTOR pathway signaling in PI3Kalpha mutant expressing human MCF7.1 cells xenografted in nu/nu mice, indicated by decreased phosphorylation of Akt, Pras40, and S6RP. GNE-490 shows high oral bioavailability and moderate to high protein binding in mouse plasma. It has favorable pharmacokinetic parameters, including clearance, volume of distribution, area under the curve, and half-life. Furthermore, it demonstrates strong antitumor activity, resulting in tumor growth inhibition in human MCF7.1 cells expressing PI3Kalpha mutant xenografted in nu/nu mice..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. GNE-490 has >200 fold selectivity for mTOR (IC50 = 750 nM).
靶点活性	PI3Kδ:5.2 nM, PI3Kβ:25 nM, PI3Kγ:15 nM, mTOR:750 nM, PI3Kα:3.5 nM

化学信息

分子量	386.47
分子式	C₁₈H₂₂N₆O₂S
CAS No.	1033739-92-2
Smiles	Cc1nc(N)ncc1-c1nc(N2CCOCC2)c2sc(cc2n1)C(C)(C)O
密度	no data available
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (129.38 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5875 mL	12.9376 mL	25.8752 mL	129.3761 mL
5 mM	0.5175 mL	2.5875 mL	5.1750 mL	25.8752 mL
10 mM	0.2588 mL	1.2938 mL	2.5875 mL	12.9376 mL
20 mM	0.1294 mL	0.6469 mL	1.2938 mL	6.4688 mL
50 mM	0.0518 mL	0.2588 mL	0.5175 mL	2.5875 mL
100 mM	0.0259 mL	0.1294 mL	0.2588 mL	1.2938 mL