DI-82

Name: DI-82
Brand: TargetMol
SKU: T39114
Rating: 4.5 (1 reviews)

还可以

产品编号 T39114Cas号 1638148-50-1

DI-82 is a highly potent inhibitor of deoxycytidine kinase (dCK), displaying impressive biochemical activity with an IC50 value of 27.8 nM and a K i value of 9.2 nM. Additionally, DI-82 exhibits significant antitumor effects.

DI-82

还可以

产品编号 T39114Cas号 1638148-50-1

规格	价格	库存	数量
2 mg	¥ 2,490	5日内发货

大包装 & 定制

加入购物车

TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

DI-82 相关产品

联系我们获取更多批次信息

资源下载

产品操作手册

产品介绍

生物活性

产品描述	DI-82 is a highly potent inhibitor of deoxycytidine kinase (dCK), displaying impressive biochemical activity with an IC50 value of 27.8 nM and a K i value of 9.2 nM. Additionally, DI-82 exhibits significant antitumor effects.
靶点活性	DCK:27.8 nM (IC50app), DCK:9.2 nM (Kiapp)
体外活性	DI-82 (compound 12R) has an IC 50 of 3.7 nM in CCRF-CEM acute lymphoblastic leukemia cells[1]. DI-82 (1 μM) has a NADPH-dependent CL int of 22.7 μL/min?mg and a NADPH-dependent T 1/2 of 102 mins in a standard microsomal liver clearance assay[1]. DI-82 (200?μM) completely blunts the ability of decitabine to bind human thymidylate synthase (TS)[2].