规格

价格

库存

数量

1 mg

¥ 1,090

现货

5 mg

¥ 2,650

现货

10 mg

¥ 3,980

现货

25 mg

¥ 6,270

现货

50 mg

¥ 8,460

现货

100 mg

¥ 11,300

现货

200 mg

¥ 15,300

现货

生物活性

产品描述	AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies.
体外活性	AZD-9574 inhibits PARP1 with IC50s range between 0.3-2 nM in all tested cell lines which is >8000-fold selectivity compared to PARP2, PARP3, PARP5a and PARP6[1].
体内活性	In an intracranial xenograft mice model of breast cancer brain metastases, AZD-9574 (3 mg/kg) shows sustained tumour growth suppression and results in a significantly extended survival of mice[1].