Name: BAY-7598
Brand: TargetMol
SKU: T10474
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

¥ 26,600

3-6月

50 mg

¥ 33,800

3-6月

100 mg

¥ 42,500

3-6月

生物活性

产品描述	BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12).
靶点活性	MMP12 (murine):0.67 nM , MMP12 (human):0.085 nM , MMP12 (rat):1.1 nM
体外活性	BAY-7598 inhibits human MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP13, MMP14, and MMP16 (IC50s: 44, 360, 600, 15, 460, 12, 67, 250, and 940 nM). BAY-7598 inhibits murine MMP2, MMP3, MMP7, MMP8, and MMP9 (IC50s: 45, 270, 130, 54, and 210 nM). BAY-7598 inhibits rat MMP2, MMP8, and MMP9 (IC50s: 45, 67, and 1000 nM).
体内活性	BAY-7598 has moderate terminal elimination half-life (t1/2=4.1 h and 4.6 h for mouse (5.0 mg/kg, p.o.), mouse (0.3 mg/kg, iv), respectively).

化学信息

分子量	505.56
分子式	C₂₈H₃₁N₃O₆
CAS No.	1816257-74-5
Smiles	C([C@H]1[C@H](C(O)=O)[C@@H](C(=O)C2=CC=C(OCCC3CCOCC3)C=C2)CC1)N4C(=O)C=5C(N=N4)=CC=CC5
密度	1.39 g/cm3 (Predicted)