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BC-23

Name: BC-23
Brand: TargetMol
SKU: T26754
Price: 786 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: NSC-45382, NSC45382, NSC 45382, BC23, BC 23

货号 T26754Cas号 6298-15-3 一键复制产品信息纯度: 99.99%

很棒

BC-23 (NSC 45382) 是一种有效的蛋白酶体抑制剂，具有抗肿瘤和抗菌活性。BC-23 抑制蛋白酶体的 CT-L 活性，可用于研究白血病，淋巴瘤，神经胶质瘤，乳腺癌和小细胞肺癌。

BC-23

一键复制产品信息

很棒

纯度: 99.99%

货号 T26754Cas号 6298-15-3

别名 NSC-45382, NSC45382, NSC 45382, BC23, BC 23

规格	价格	库存
1 mg	¥ 786	现货
5 mg	¥ 1,990	现货
10 mg	¥ 3,180	现货
25 mg	¥ 5,130	现货
50 mg	¥ 6,930	现货
100 mg	¥ 9,550	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.99%

颜色: 橙色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

BC-23 AI Summary

BC-23 exhibits a broad range of bioactivities, including potent inhibitory effects on chymotrypsin-like, trypsin-like, and PGPH activities of the rabbit 26S proteasome, with varied IC50 values. It also inhibits 26S proteasome-mediated chymotrypsin-like activity in human MCF7 cells. Additionally, BC-23 shows strong inhibition of calpain (IC50 > 30000.0 nM) and moderate inhibitory activity against chymotrypsin-like activity of the human 20S proteasome (IC50 18560.0 nM). It affects multiple molecular pathways, including the beta catenin/Tcf4 and Wnt/beta-catenin transcriptional activities with IC50 values of 1700.0 nM and 2300.0 nM, respectively. The compound also demonstrates antiproliferative activity across various human cancer cell lines such as KBVIN, KB, DU145, A549, and MCF7, with IC50 values ranging from 9570.0 nM to 12190.0 nM, including specific inhibition of MCF7 cell growth (IC50 1960.0 nM). Moreover, BC-23 inhibits enzymes such as HSD17B4, Cytochrome P450 (2C19, 2D6, 2C9), ALDH1A1, hydroxyacyl-Coenzyme A dehydrogenase, and HPGD. It also shows activity in erasing genomic imprints and modulating the Hypoxia Response Element Signaling Pathway, and demonstrates varying potency in inhibiting the growth of several human tumor cell lines, indicating its potential as a multi-target anticancer agent..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	BC-23 (NSC 45382) is a potent proteasome inhibitor with antitumor and antimicrobial activity.BC-23 inhibits the CT-L activity of the proteasome and is used in the study of leukemias, lymphomas, gliomas, breast cancer, and small cell lung cancer.
别名	NSC-45382, NSC45382, NSC 45382, BC23, BC 23

化学信息

分子量	439.87
分子式	C₂₁H₁₄ClN₃O₄S
CAS No.	6298-15-3
Smiles	O=C1C=2C(C(=O)C(Cl)=C1NC3=CC=C(S(NC4=CC=CC=N4)(=O)=O)C=C3)=CC=CC2
密度	1.56 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 20 mg/mL (45.47 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2734 mL	11.3670 mL	22.7340 mL	113.6699 mL
5 mM	0.4547 mL	2.2734 mL	4.5468 mL	22.7340 mL
10 mM	0.2273 mL	1.1367 mL	2.2734 mL	11.3670 mL
20 mM	0.1137 mL	0.5683 mL	1.1367 mL	5.6835 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。