Powder: -20°C for 3 years | In solvent: -80°C for 1 year
N-Desmethyl Sildenafil (UK-103,320) (Desmethylsildenafil) is a prominent metabolite of Sildenafil, a potent inhibitor of phosphodiesterase type 5 (PDE5).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 413 | 现货 | ||
5 mg | ¥ 946 | 现货 | ||
10 mg | ¥ 1,580 | 现货 | ||
25 mg | ¥ 3,160 | 现货 | ||
50 mg | ¥ 4,680 | 现货 | ||
100 mg | ¥ 6,680 | 现货 | ||
500 mg | ¥ 13,500 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,090 | 现货 |
产品描述 | N-Desmethyl Sildenafil (UK-103,320) (Desmethylsildenafil) is a prominent metabolite of Sildenafil, a potent inhibitor of phosphodiesterase type 5 (PDE5). |
体外活性 | N-Desmethyl Sildenafil increases the amplitude of electroretinogram (ERG) recorded from the dark-adapted isolated rat retina, most probably through the enhancement of the photoreceptor cell response[1]. The formation of N-Desmethyl Sildenafil is examined using CYP3A supersomes co-expressing human P450 oxidoreductase and cytochrome b5. N-Desmethyl Sildenafil is catalyzed by CYP3A4, CYP3A5, and to a lesser extent by CYP3A7[2]. |
别名 | Desmethylsildenafil, UK-103,320 |
分子量 | 460.55 |
分子式 | C21H28N6O4S |
CAS No. | 139755-82-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 5 mg/mL
DMSO:PBS (pH 7.2)(1:5): 0.15 mg/mL
DMSO: 225 mg/mL (488.5 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1713 mL | 10.8566 mL | 21.7132 mL | 54.2829 mL |
5 mM | 0.4343 mL | 2.1713 mL | 4.3426 mL | 10.8566 mL | |
10 mM | 0.2171 mL | 1.0857 mL | 2.1713 mL | 5.4283 mL | |
20 mM | 0.1086 mL | 0.5428 mL | 1.0857 mL | 2.7141 mL | |
50 mM | 0.0434 mL | 0.2171 mL | 0.4343 mL | 1.0857 mL | |
100 mM | 0.0217 mL | 0.1086 mL | 0.2171 mL | 0.5428 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
N-Desmethyl Sildenafil 139755-82-1 Metabolism Drug Metabolite Desmethylsildenafil UK-103,320 Inhibitor inhibitor inhibit