规格

价格

库存

数量

1 mg

¥ 823

现货

5 mg

¥ 2,320

现货

10 mg

¥ 3,560

现货

25 mg

¥ 5,690

现货

50 mg

¥ 7,690

现货

100 mg

¥ 9,870

现货

200 mg

¥ 13,800

现货

1 mL x 10 mM (in DMSO)

¥ 2,160

现货

生物活性

产品描述	Bozitinib (PLB-1001) (PLB-1001) is a highly selective inhibitor of the c-MET kinase with blood-brain barrier permeability. Bozitinib binds to the conventional ATP-binding pocket of the tyrosine kinase superfamily.
体外活性	Bozitinib (30 μM; 6 hours) inhibits the phosphorylation of MET and STAT3. Bozitinib has a robust inhibitory effect on MET and its downstream signaling pathways.
别名	PLB-1001, CBT-101

化学信息

分子量	424.38
分子式	C₂₀H₁₅F₃N₈
CAS No.	1440964-89-5
Smiles	Cn1cc2cc(c(F)cc2n1)C(F)(F)c1nnc2ccc(nn12)-c1cnn(c1)C1CC1
密度	1.68 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 30 mg/mL (70.69 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.71 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO