规格

价格

库存

数量

1 mg

¥ 495

现货

5 mg

¥ 1,160

现货

10 mg

¥ 1,890

现货

25 mg

¥ 3,820

现货

50 mg

¥ 5,550

现货

100 mg

¥ 7,770

现货

500 mg

¥ 15,500

现货

1 mL x 10 mM (in DMSO)

¥ 1,290

现货

生物活性

产品描述	CC-671 is a dual TTK protein kinase (IC50: 0.005 μM) /CLK2 (IC50: 0.006 μM) inhibitor.
靶点活性	CLK2:0.006 μM, TTK:0.005 μM
体外活性	HCT-116细胞裂解物经3 μM的CC-671处理1小时后的结果表明，仅有四种激酶展示了75%或更高的细胞结合量，包括CLK2、CAMKK2、PIP4K22和JNK[1]。
体内活性	CC-671在10mg/kg和20mg/kg剂量下，每3天给药一次的方案中显示出显著的肿瘤生长抑制效果，抑制率达71%（（vehicle-treated/vehicle）×100%）。在20mg/kg剂量的CC-671处理组中，体重损失比10mg/kg组更高（17%对比5%）[1]。
激酶实验	The kinase selectivity profile of CC-671 is assessed. The screen is conducted with the concentration of CC-671 held constant at 3 μM. The TTK binding affinity is measured using the kinase binding assays. The kinase binding assays are based on the binding and displacement of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold[1].
动物实验	Female SCID mice are inoculated subcutaneously with 5×106 Cal-51 cells. Mice with tumours of approximately 125 mm3 are randomized and treated intravenously at various doses and schedules of CC-671 (n=8 to10/group). Tumours are measured twice a week for the duration of the study. The long and short axes of each a tumour are measured using a digital calliper in millimetres and the tumour volumes are calculated[1].

化学信息

分子量	512.56
分子式	C₂₈H₂₈N₆O₄
CAS No.	1618658-88-0
Smiles	CNC(=O)c1ccc(Nc2nc(OC3CCCC3)c3c(c[nH]c3n2)-c2ccc3nc(C)oc3c2)c(OC)c1
密度	1.351 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 120 mg/mL (234.12 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Saline: < 10 mg/mL (19.51 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (19.51 mM), Solution.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9510 mL	9.7550 mL	19.5099 mL	97.5496 mL
5 mM	0.3902 mL	1.9510 mL	3.9020 mL	19.5099 mL
10 mM	0.1951 mL	0.9755 mL	1.9510 mL	9.7550 mL
20 mM	0.0975 mL	0.4877 mL	0.9755 mL	4.8775 mL
50 mM	0.0390 mL	0.1951 mL	0.3902 mL	1.9510 mL
100 mM	0.0195 mL	0.0975 mL	0.1951 mL	0.9755 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

CC-671

CC-671

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词

CC-671

CC-671

CC-671 相关产品

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词