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Acefylline

Name: Acefylline
Brand: TargetMol
SKU: T2205
Price: 132 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 茶碱乙酸, Theophyllineacetic acid, Theophylline-7-acetic acid, Carboxymethyltheophylline, acetyloxytheophylline

货号 T2205Cas号 652-37-9 一键复制产品信息纯度: 99.57%

很棒

Acefylline (Theophylline-7-acetic acid) 是黄嘌呤衍生物，是一种腺苷受体拮抗剂。它是蛋白质精氨酸脱亚氨酶 (PAD) 激活剂，也是一种支气管扩张剂，可抑制大鼠肺 cAMP 磷酸二酯酶同工酶。

Acefylline

一键复制产品信息

很棒

纯度: 99.57%

货号 T2205Cas号 652-37-9

别名 茶碱乙酸, Theophyllineacetic acid, Theophylline-7-acetic acid, Carboxymethyltheophylline, acetyloxytheophylline

规格	价格	库存
25 mg	¥ 132	现货
50 mg	¥ 178	现货
100 mg	¥ 247	现货
500 mg	¥ 572	现货
1 g	¥ 837	现货
1 mL x 10 mM (in DMSO)	¥ 272	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.57%

颜色: 白色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

Acefylline AI Summary

Acefylline demonstrates a broad spectrum of bioactivities. It binds to the human Adenosine A2B receptor with a Ki value of 27600.0 nM, indicating notable affinity. In cellular assays, it exhibits minimal impact on calcium ion release in PC12 cells, showing only 1.4% of the effect of 1 mM Caffeine. Additionally, it has shown antiviral potentials, particularly against Ebola virus with AC50 values ranging from 39.81 uM to 39810.7 nM for inhibiting viral entry. Against SARS-CoV-2, Acefylline inhibits virus-induced cytotoxicity in Caco-2 cells by 20.97% at 10 uM concentration over 48 hours, and has a hit score of 0.1779 in HRCE cells at MOI 0.4 after 96 hours. It also shows a weak inhibitory effect on SARS-CoV-2 3CL-Pro protease with 12.99% inhibition at 20 µM. However, it displays minimal inhibition of cell viability in Vero E6 cells infected with SARS-CoV-2 and has an IC50 greater than 20000.0 nM in inhibiting SARS-CoV-2 induced cytotoxicity in VERO-6 cells. Lastly, it has shown weak inhibitory activity against human HDAC6, with -7.47% and -3.53% in assays using commercial and custom peptide substrates, respectively..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Acefylline (Theophylline-7-acetic acid), a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the pharmaceutical preparation Etanautine to help offset its stimulant effects
别名	茶碱乙酸, Theophyllineacetic acid, Theophylline-7-acetic acid, Carboxymethyltheophylline, acetyloxytheophylline

化学信息

分子量	238.2
分子式	C₉H₁₀N₄O₄
CAS No.	652-37-9
Smiles	CN1C2=C(N(CC(O)=O)C=N2)C(=O)N(C)C1=O
密度	1.64 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 111.11 mg/mL (466.46 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (41.98 mM), Solution.

10% DMSO+90% Saline: < 10 mg/mL (41.98 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1982 mL	20.9908 mL	41.9815 mL	209.9076 mL
5 mM	0.8396 mL	4.1982 mL	8.3963 mL	41.9815 mL
10 mM	0.4198 mL	2.0991 mL	4.1982 mL	20.9908 mL
20 mM	0.2099 mL	1.0495 mL	2.0991 mL	10.4954 mL
50 mM	0.0840 mL	0.4198 mL	0.8396 mL	4.1982 mL
100 mM	0.0420 mL	0.2099 mL	0.4198 mL	2.0991 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。