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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Nitidine chloride

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纯度: 99.55%

货号 T5S0761Cas号 13063-04-2

别名 氯化两面针碱

Nitidine chloride 是从Zanthoxylum nitidum (Roxb) DC 中分离得到的，具有抗疟疾活性。它通过多个靶点通路，起抗癌作用，抑制STAT3、DNA 拓扑异构酶1和2A、ERK 和c-Src/FAK 相关信号通路。它通过MAPK 和NF-kB 途径抑制Lps 诱导的炎性细胞因子的产生。

Nitidine chloride
其他形式的 “Nitidine chloride”:
Nitidine chloride (Standard)
NITIDINE

Nitidine chloride

一键复制产品信息
Rating icon 很棒

纯度: 99.55%

货号 T5S0761 别名 氯化两面针碱Cas号 13063-04-2

Nitidine chloride 是从Zanthoxylum nitidum (Roxb) DC 中分离得到的，具有抗疟疾活性。它通过多个靶点通路，起抗癌作用，抑制STAT3、DNA 拓扑异构酶1和2A、ERK 和c-Src/FAK 相关信号通路。它通过MAPK 和NF-kB 途径抑制Lps 诱导的炎性细胞因子的产生。

规格价格库存数量
1 mg
¥ 248
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5 mg
¥ 638
现货
10 mg
¥ 1,130
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25 mg
¥ 1,850
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50 mg
¥ 2,780
现货
100 mg
¥ 4,130
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500 mg
¥ 8,820
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纯度: 99.55%
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产品介绍

Nitidine chloride AI Summary
Nitidine chloride exhibits a wide range of bioactivities, demonstrating significant anticancer, antimicrobial, and antiviral properties. In mouse models, it shows potential anticancer activity against L1210 and M5076 sarcoma with T/C values of 136.0 and 137.0, respectively, at a dosage of 100 mg/kg, as well as against P388 lymphocytic leukemia with a T/C value of 129.0% at the same dose. Additionally, it exhibits potent activity against various human cancer cell lines, including human KB cells (ED50 of 4.3 µg/mL), HeLa S3 cells (IC50 of 0.05 µg/mL), HT-29 cells (IC50 of 2750.0 nM), HCT116 (IC50 of 4420.0 nM), HepG2 (IC50 of 3520.0 nM), and HL60 (IC50 of 3410.0 nM). It has also shown promising results in NCI's anticancer drug screening program with a GI50 value of 125.0 nM against a human cancer cell line. In addition to its anticancer effects, Nitidine chloride inhibits the growth of Plasmodium falciparum strains with an IC50 of 400.0 nM and demonstrates antiviral activity against HIV1 RF in human CEM-SS cells with an EC50 of 14000.0 nM. It also shows inhibitory effects on HIV1 RT at an IC50 value of less than 50.0 µg/mL and on AMV reverse transcriptase at concentrations of 40-50 µg/mL resulting in 50% enzyme inhibition. Moreover, it has been effective in inhibiting human DNA ligase 1 with an IC50 of 25.0 µg/mL, and human T-cell proliferation with an IC50 of 400.0 nM. Nitidine chloride also possesses broad antimicrobial and antifungal activities, with significant growth inhibition of Micrococcus luteus, Staphylococcus aureus, Mycobacterium smegmatis, Mycobacterium avium, Candida albicans, Cryptococcus neoformans, Saccharomyces cerevisiae, and Aspergillus niger. These findings highlight Nitidine chloride as a molecule with diverse therapeutic potentials, warranting further investigation and development..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and identifies efficacy in vivo in a mouse model of HCC.
别名氯化两面针碱
化学信息
分子量383.82
分子式C21H18ClNO4
CAS No.13063-04-2
Smiles[Cl-].COc1cc2c[n+](C)c3c(ccc4cc5OCOc5cc34)c2cc1OC
密度1.35g/cm3
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble
DMSO: 3.84 mg/mL (10 mM), Sonication is recommended.
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM2.6054 mL13.0269 mL26.0539 mL130.2694 mL
5 mM0.5211 mL2.6054 mL5.2108 mL26.0539 mL
10 mM0.2605 mL1.3027 mL2.6054 mL13.0269 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

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关键词

TopoisomeraseSTATPTK2 protein tyrosine kinase 2PTK2Parasitep38MAPKp38 MAPKNuclear factor-κBNuclear factor-kappaBNitidine chlorideNitidineNF-κBNFκBNF-kBNFkBInhibitorinhibitFocal adhesion kinaseFAKExtracellular signal regulated kinasesERKApoptosis
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