L-Isoleucine

Name: L-Isoleucine
Brand: TargetMol
SKU: T0063
Price: 110 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.62%

货号 T0063Cas号 73-32-5

别名 异亮氨酸, L-异亮氨酸, isoleucine, Ile

L-Isoleucine (Ile) 是一种非极性疏水性氨基酸。它是必需氨基酸。

L-Isoleucine

一键复制产品信息

很棒

纯度: 99.62%

货号 T0063 别名 异亮氨酸, L-异亮氨酸, isoleucine, IleCas号 73-32-5

L-Isoleucine (Ile) 是一种非极性疏水性氨基酸。它是必需氨基酸。

规格	价格	库存	数量
50 mg	¥ 150	现货
1 mL x 10 mM (in H2O)	¥ 110	现货

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COA HNMR LCMS 产品操作手册

产品介绍

L-Isoleucine AI Summary

L-Isoleucine inhibits human PAT1-mediated L-[3H]proline uptake in human Caco2 cells with a Ki value of 37,000,000 nM and a pKi value of -1.57 mM. It also acts as a substrate and inhibitor of the LAT1 amino acid transporter. Specifically, it inhibits gabapentin uptake by LAT1 with an IC50 of 140,000 nM in a cis-inhibition assay and induces gabapentin efflux with 93% activity in a trans-stimulation assay. Furthermore, it exhibits a substrate activity of 2.5 fmol/min for LAT1 and shows an IC50 of 150,000 nM in an LAT1 inhibition assay. In addition, L-Isoleucine demonstrates antiviral activity against the SARS-CoV-2 virus (USA-WA1/2020 strain) with a hit score of 0.09121 in HRCE cells at MOI 0.4 after 96 hours, though it does not meet the hit classification threshold. Lastly, the compound has an inhibition rate of 20% against PKM2 from an unspecified origin..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	L-Isoleucine (Ile) is an essential branched-chain aliphatic amino acid found in many proteins. It is an isomer of LEUCINE. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels.
别名	异亮氨酸, L-异亮氨酸, isoleucine, Ile

化学信息

分子量	131.17
分子式	C₆H₁₃NO₂
CAS No.	73-32-5
Smiles	[C@H]([C@H](CC)C)(C(O)=O)N
密度	1.207 g/cm3. Temperature:20 °C.
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 25.1 mg/mL (191.35 mM), Sonication is recommended.

DMSO: Insoluble

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	7.6237 mL	38.1185 mL	76.2369 mL	381.1847 mL
5 mM	1.5247 mL	7.6237 mL	15.2474 mL	76.2369 mL
10 mM	0.7624 mL	3.8118 mL	7.6237 mL	38.1185 mL
20 mM	0.3812 mL	1.9059 mL	3.8118 mL	19.0592 mL
50 mM	0.1525 mL	0.7624 mL	1.5247 mL	7.6237 mL
100 mM	0.0762 mL	0.3812 mL	0.7624 mL	3.8118 mL