P-1075

Name: P-1075
Brand: TargetMol
SKU: T16420
Price: 413 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.85%

货号 T16420Cas号 60559-98-0

P-1075 是磺酰脲受体2相关的 ATP 敏感性的钾通道(SUR2-KIR6)的激活剂，EC50为 45 nM。它在兔子中通过打开线粒体 K (ATP) 通道产生活性氧，产生保护心脏的功效。

为众多的药物研发团队赋能，

让新药发现更简单！

P-1075

一键复制产品信息

很棒

纯度: 99.85%

货号 T16420Cas号 60559-98-0

规格	价格	库存
1 mg	¥ 413	现货
5 mg	¥ 826	现货
10 mg	¥ 1,380	现货
25 mg	¥ 2,790	现货
50 mg	¥ 4,780	现货
100 mg	¥ 6,650	现货
200 mg	¥ 8,960	现货
1 mL x 10 mM (in DMSO)	¥ 1,050	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.85%

联系我们获取更多批次信息

资源下载:

COA LCMS 产品操作手册

产品介绍

P-1075 AI Summary

P-1075 exhibits diverse bioactivities, including ionization constants with pKa1 at 2.61 and pKa2 at 12.18. It shows potent bioactivity in various assays: it induces a 15% increase in [86Rb+] efflux from rat portal vein at a concentration with a pEC15 of 7.4, inhibits spontaneous activity with an IC50 of 1.995 nM, and has binding affinities with a Ki of 27.0 nM in canine cardiac membranes and a Hill coefficient of 1.17. It requires an EC50 of 60.0 nM to delay contracture onset in ischemic rat hearts and shows inhibition of methoxamine-induced contractions in rat aorta with an IC50 of 4.4 nM. Additionally, it modulates K-ATP channels, with EC50 values of 44.67 nM and 85.11 nM in guinea pig and landrace pig bladder assays, respectively, and shows vasorelaxant activity in rat aorta (IC50 250.0 nM), though it is weakly active against rat mitochondrial ATP hydrolase (IC50 > 100,000 nM). P-1075 displays hypotensive effects, effective at doses as low as 0.1 mg/kg, but is toxic at higher doses (LD50 14 mg/kg). It also exhibits antibacterial and antiviral properties, showing various inhibition percentages against pathogens and high IC50 values (>20,000 nM) for SARS-CoV-2 antiviral activity. Lastly, it has a complex impact on cell viability, enhancing growth in some cell lines while suppressing it in others..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	P-1075 is a potent sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-KIR6) activator (EC50 = 45 nM). P-1075 opens opens mitoKATP channels and may be cardioprotective.
靶点活性	SUR2-KIR6:45 nM(EC50)

化学信息

分子量	231.3
分子式	C₁₂H₁₇N₅
CAS No.	60559-98-0
Smiles	CCC(C)(C)N\C(NC#N)=N\c1cccnc1
密度	1.07 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 250 mg/mL (1080.85 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (21.62 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3234 mL	21.6169 mL	43.2339 mL	216.1695 mL
5 mM	0.8647 mL	4.3234 mL	8.6468 mL	43.2339 mL
10 mM	0.4323 mL	2.1617 mL	4.3234 mL	21.6169 mL
20 mM	0.2162 mL	1.0808 mL	2.1617 mL	10.8085 mL
50 mM	0.0865 mL	0.4323 mL	0.8647 mL	4.3234 mL
100 mM	0.0432 mL	0.2162 mL	0.4323 mL	2.1617 mL