Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PI-103 Hydrochloride 是一种有效的PI3K 和mTOR 双重抑制剂,抑制p110α,p110β,p110δ,p110γ,mTORC1和mTORC2,IC50分别为 8 nM,88 nM,48 nM,150 nM,20 nM 和 83 nM。PI-103 Hydrochloride 也可抑制DNA-PK,IC50为 2 nM。PI-103 Hydrochloride 诱导细胞自噬 (autophagy)。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 489 | 5日内发货 | ||
5 mg | ¥ 822 | 5日内发货 | ||
10 mg | ¥ 1,280 | 5日内发货 | ||
25 mg | ¥ 1,980 | 5日内发货 | ||
1 mL * 10 mM (in DMSO) | ¥ 885 | 5日内发货 |
PI-103 Hydrochloride 的其他形式现货产品:
产品描述 | PI-103 Hydrochloride is a potent dual inhibitor of PI3K and mTOR, demonstrating inhibitory IC50 values of 8 nM for p110α, 88 nM for p110β, 48 nM for p110δ, 150 nM for p110γ, 20 nM for mTORC1, and 83 nM for mTORC2, respectively. Additionally, it inhibits DNA-PK with an IC50 of 2 nM and induces autophagy [1] [2] [3] [4]. |
体外活性 | PI-103 shows antiproliferative properties in a panel of human cancer cell lines [1]. PI-103 is essentially cytostatic for cell lines and induced cell cycle arrest in the G1 phase. In blast cells, PI-103 inhibits leukemic proliferation, the clonogenicity of leukemic progenitors and induces mitochondrial apoptosis, especially in the compartment containing leukemic stem cells [2]. PI-103 potently inhibits both the rapamycin-sensitive (mTORC1, IC 50 =20 nM) and rapamycin-insensitive (mTORC2, IC 50 =83 nM) complexes of the protein kinase mTOR [4]. |
体内活性 | PI-103 shows therapeutic activity against a range of human tumor xenografts, exhibiting inhibition of angiogenesis, invasion, metastasis, and direct antiproliferative effects [1]. PI-103 induces immunosuppression promoting in vivo tumor growth and inhibiting apoptosis. Tumors from PI-103-treated mice shows higher levels of cyclin D1 and more proliferating cells [3]. |
分子量 | 384.82 |
分子式 | C19H17ClN4O3 |
CAS No. | 371935-79-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PI-103 Hydrochloride 371935-79-4 PI103 Hydrochloride PI 103 Hydrochloride Inhibitor inhibitor inhibit