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Denatonium benzoate

Name: Denatonium benzoate
Brand: TargetMol
SKU: T1098
Price: 236 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.98%

货号 T1098Cas号 3734-33-6

别名 苯甲地那铵, THS-839

Denatonium benzoate (THS-839) 是一种已知的最苦的化合物，可作为厌恶剂(苦味剂)，加入到工业酒精、防冻液、咬指甲癖预防、呼吸器面罩配合测试、动物驱虫剂、液体皂和洗发水中，防止不适当的摄取。

Denatonium benzoate

一键复制产品信息

很棒

纯度: 99.98%

货号 T1098 别名 苯甲地那铵, THS-839Cas号 3734-33-6

规格	价格	库存
50 mg	¥ 236	现货
100 mg	¥ 413	现货
200 mg	¥ 588	现货
500 mg	¥ 980	现货
1 mL x 10 mM (in DMSO)	¥ 455	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.98%

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资源下载:

COA HNMR HPLC 产品操作手册

产品介绍

Denatonium benzoate AI Summary

Denatonium benzoate exhibits a variety of bioactivities, including potent inhibition of the Menin-MLL interaction in MLL-related leukemias and modulation of Lamin A splicing. It functions as an agonist of the Thyroid Stimulating Hormone Receptor, thereby activating intracellular cAMP concentrations. Additionally, Denatonium benzoate acts as both an inhibitor and substrate of Cytochrome P450 2D6 and inhibits USP1/UAF1, as well as human tyrosyl-DNA phosphodiesterase 1 (TDP1) in the presence or absence of CPT. The compound also blocks Ebola Virus entry across different screening assays. In terms of antiviral properties, Denatonium benzoate demonstrates modest activity against SARS-CoV-2 in various assays. It shows an inhibition index of 0.341 for inhibiting cell viability in Vero E6 cells infected with SARS-CoV-2 strain BavPat1 and exhibits an 8.55% inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 cells at a concentration of 10 µM after 48 hours. However, it exhibits a low inhibition rate of -0.13% in VERO-6 cells. Furthermore, Denatonium benzoate interacts with the human TAS2R10 receptor, with a threshold concentration of 0.003 mM to induce a calcium response in HEK-293T-Galpha16-gustducin44 cells, and shows an EC50 value of 70,000 nM for calcium response in the same assay. It also exhibits a 10.09% inhibition of the SARS-CoV-2 3CL-Pro protease at a concentration of 20 µM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Denatonium benzoate (THS-839) , a quaternary ammonium cation, is a compound of a salt with an inert anion like saccharide or benzoate. Its structure is involved in the local anesthetic lidocaine which difference only is the addition of a benzyl group to the amino nitrogen.
别名	苯甲地那铵, THS-839

化学信息

分子量	446.58
分子式	C₂₈H₃₄N₂O₃
CAS No.	3734-33-6
Smiles	c1cccc(c1)C(=O)[O-].[N+](CC(=O)Nc1c(cccc1C)C)(CC)(CC)Cc1ccccc1
密度	1.1256 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 27.5 mg/mL (61.58 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.48 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2392 mL	11.1962 mL	22.3924 mL	111.9620 mL
5 mM	0.4478 mL	2.2392 mL	4.4785 mL	22.3924 mL
10 mM	0.2239 mL	1.1196 mL	2.2392 mL	11.1962 mL
20 mM	0.1120 mL	0.5598 mL	1.1196 mL	5.5981 mL
50 mM	0.0448 mL	0.2239 mL	0.4478 mL	2.2392 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

THS839 THS 839 Inhibitor inhibit Denatonium Benzoate Denatonium

Denatonium benzoate

Denatonium benzoate