规格

价格

库存

数量

1 mg

¥ 762

现货

5 mg

¥ 1,890

现货

10 mg

¥ 2,970

现货

25 mg

¥ 4,950

现货

50 mg

¥ 6,860

现货

100 mg

¥ 9,230

现货

200 mg

¥ 12,300

现货

1 mL x 10 mM (in DMSO)

¥ 1,670

现货

生物活性

产品描述	Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0 μM, respectively).
靶点活性	P-gp:73.8 μM , Dopamine β-hydroxylase:, BCRP:17.0 μM
体内活性	In the Dahl SS rat, Zamicastat (10, 30 and 100 mg/kg/day; oral bolus, 7 days) is tested acutely against salt-induced hypertension. Zamicastat produces a dose-dependent decrease in blood pressure[2].
别名	BIA 5-1058

化学信息

分子量	401.47
分子式	C₂₁H₂₁F₂N₃OS
CAS No.	1080028-80-3
Smiles	Fc1cc(F)c2OC[C@@H](Cc2c1)n1c(CCNCc2ccccc2)c[nH]c1=S
密度	1.36 g/cm3 (Predicted)
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 150 mg/mL (373.63 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.96 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO