Letaxaban

Name: Letaxaban
Brand: TargetMol
SKU: T68092
Price: 1020 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.87%

货号 T68092Cas号 870262-90-1

别名 利他沙班, TAK-442

Letaxaban (TAK-442) 是一种口服活性的四氢嘧啶-2(1H)- 1衍生物和具有抗凝血活性的凝血因子Xa(激活因子X)抑制剂。Letaxaban 不影响出血时间。Letaxaban 已被用于研究静脉血栓栓塞和急性冠状动脉综合征的治疗和预防的试验。

Letaxaban

一键复制产品信息

很棒

纯度: 99.87%

货号 T68092 别名 利他沙班, TAK-442Cas号 870262-90-1

规格	价格	库存
1 mg	¥ 1,020	现货
5 mg	¥ 2,630	现货
10 mg	¥ 3,790	现货
25 mg	¥ 5,870	现货

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纯度: 99.87%

ee: 100%

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产品介绍

Letaxaban AI Summary

Letaxaban exhibits metabolic stability in both human and monkey liver microsomes, showing no acid production after 2 hours. It demonstrates potent anticoagulant activity in human plasma, with an effective concentration of 0.58 µM to double prothrombin time, and significant inhibition of human factor 10a with an IC50 value of 3.5 nM and Ki of 1.8 nM. Selectivity ratios indicate a preference for factor 10a over other bioactivities tested. In a rabbit venous thrombosis model, Letaxaban shows dose-dependent inhibition of venous thrombus formation when administered intravenously. Additionally, it has a promising oral bioavailability of 52.5% in monkeys, with clearance and volume of distribution at steady state measured at 11.8 mL.min-1.kg-1 and 0.579 L.kg-1, respectively..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Letaxaban (TAK-442) is a small molecule Xa factor inhibitor that can be used to study polar coronary syndromes and thrombotic blockages.
别名	利他沙班, TAK-442

化学信息

分子量	479.98
分子式	C₂₂H₂₆ClN₃O₅S
CAS No.	870262-90-1
Smiles	ClC1=CC2=C(C=C(S(C[C@H](C(=O)N3CCC(CC3)N4C(=O)NCCC4)O)(=O)=O)C=C2)C=C1

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (104.17 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0834 mL	10.4171 mL	20.8342 mL	104.1710 mL
5 mM	0.4167 mL	2.0834 mL	4.1668 mL	20.8342 mL
10 mM	0.2083 mL	1.0417 mL	2.0834 mL	10.4171 mL
20 mM	0.1042 mL	0.5209 mL	1.0417 mL	5.2086 mL
50 mM	0.0417 mL	0.2083 mL	0.4167 mL	2.0834 mL
100 mM	0.0208 mL	0.1042 mL	0.2083 mL	1.0417 mL