LIMK-IN-22j

Name: LIMK-IN-22j
Brand: TargetMol
SKU: T24410
Price: 177 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.165%

货号 T24410Cas号 1116571-01-7

别名 LIMK inhibitor-22j, LIMK inhibitor 22j, LIMK IN 22j

LIMK-IN-22j (LIMK inhibitor 22j) 是一种有效的选择性 LIMK 抑制剂。

为众多的药物研发团队赋能，

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LIMK-IN-22j

一键复制产品信息

很棒

纯度: 99.165%

货号 T24410 别名 LIMK inhibitor-22j, LIMK inhibitor 22j, LIMK IN 22jCas号 1116571-01-7

LIMK-IN-22j (LIMK inhibitor 22j) 是一种有效的选择性 LIMK 抑制剂。

规格	价格	库存
1 mg	¥ 177	现货
2 mg	¥ 250	现货
5 mg	¥ 358	现货
10 mg	¥ 520	现货
25 mg	¥ 940	现货
50 mg	¥ 1,330	现货
1 mL x 10 mM (in DMSO)	¥ 392	现货

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纯度: 99.165%

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COA HNMR LCMS 产品操作手册

产品介绍

LIMK-IN-22j AI Summary

LIMK-IN-22j exhibits potent inhibition of human recombinant LIMK2 with an IC50 of 0.9 nM and LIMK1 with an IC50 of 0.5 nM. It shows moderate inhibition of LIMK2 in pig PTM cells, reducing cofilin-phosphorylation by 50% at 10 nM. In a mouse model, it demonstrates activity against dexamethasone-induced ocular hypertension, reducing intraocular pressure by 3.7 mmHg within 1 hour at a dose of 5 µg. LIMK-IN-22j is selective towards LIMK2 over ROCK1 and ROCK2, with IC50 ratios greater than 100 and 900, respectively. Additionally, it enhances outflow facility in pig eyes by 30% at a concentration of 100 nM, as evidenced by an eye-perfusion assay..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	LIMK-IN-22j (LIMK inhibitor 22j) is an effective and selective inhibitor of LIMK.
靶点活性	LIMK1:0.9 nM, ROCK2:2700 nM, ROCK1:260 nM, LIMK2:0.5 nM
别名	LIMK inhibitor-22j, LIMK inhibitor 22j, LIMK IN 22j

化学信息

分子量	453.34
分子式	C₂₀H₂₁BrN₈
CAS No.	1116571-01-7
Smiles	C[C@H]1CN(CCN1\C(Nc1cccc(Br)c1)=N\C#N)c1ncnc2[nH]cc(C)c12
密度	1.54 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (121.32 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2058 mL	11.0292 mL	22.0585 mL	110.2925 mL
5 mM	0.4412 mL	2.2058 mL	4.4117 mL	22.0585 mL
10 mM	0.2206 mL	1.1029 mL	2.2058 mL	11.0292 mL
20 mM	0.1103 mL	0.5515 mL	1.1029 mL	5.5146 mL
50 mM	0.0441 mL	0.2206 mL	0.4412 mL	2.2058 mL
100 mM	0.0221 mL	0.1103 mL	0.2206 mL	1.1029 mL