T-0156

Name: T-0156
Brand: TargetMol
SKU: T23411L
Price: 910 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.76%

货号 T23411LCas号 324572-92-1

别名 T 0156

T-0156 是一种新型高效且具有选择性的 5 型磷酸二酯酶抑制剂，抑制环磷酸鸟苷 (cGMP) 的水解，对 PDE6、PDE1、PDE2、PDE3 和 PDE4 较低的亲和力。

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T-0156

一键复制产品信息

很棒

纯度: 98.76%

货号 T23411L 别名 T 0156Cas号 324572-92-1

T-0156 是一种新型高效且具有选择性的 5 型磷酸二酯酶抑制剂，抑制环磷酸鸟苷 (cGMP) 的水解，对 PDE6、PDE1、PDE2、PDE3 和 PDE4 较低的亲和力。

规格	价格	库存
1 mg	¥ 910	现货
5 mg	¥ 2,270	现货
10 mg	¥ 3,320	现货
25 mg	¥ 5,230	现货
50 mg	¥ 6,900	现货
100 mg	¥ 9,520	现货
200 mg	¥ 12,800	现货

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COA HNMR LCMS 产品操作手册

产品介绍

T-0156 AI Summary

T-0156 exhibits significant antiplasmodial activity against various strains of *Plasmodium falciparum*, with IC50 values ranging from 1995.26 nM to 12589.25 nM after 72 hours as measured by the SYBR green assay. It also demonstrates bioactivity as an enzyme inhibitor and activator; specifically, it inhibits Cytochrome P450 enzymes (2C19, 2D6, 2C9, and 3A4) and activates Cytochrome P450 3A4 while inhibiting Cruzain. Moreover, T-0156 is a potential modulator of lipid storage. In the context of antiviral properties, it inhibits SARS-CoV-2-induced cytotoxicity in Caco-2 and VERO-6 cells at a 10 µM concentration, with an inhibition rate of 7.91% observed in Caco-2 cells and a marginal or negligible effect (-0.13%) in VERO-6 cells. The compound also demonstrates an inhibition percentage of 24.19% on the SARS-CoV-2 3CL-Pro protease at a 20 µM concentration, indicating its role in inhibiting viral replication. Additionally, it shows inhibitory activity against human HDAC6, though with modest inhibition percentages of -23.75% and -2.58% using commercial and custom peptide substrates, respectively..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	T-0156 is a novel, potent and selective phosphodiesterase type 5 inhibitor that inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) with low affinity for PDE6, PDE1, PDE2, PDE3 and PDE4.
别名	T 0156

化学信息

分子量	583.59
分子式	C₃₁H₂₉N₅O₇
CAS No.	324572-92-1
Smiles	O=C(OC)C1=C(C=2C=C(OC)C(OC)=C(OC)C2)C=3C=CN=C(OCC4=NC=CC=N4)C3C(=O)N1CC=5C=CN=C(C5)C
密度	1.329 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (94.24 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7135 mL	8.5677 mL	17.1353 mL	85.6766 mL
5 mM	0.3427 mL	1.7135 mL	3.4271 mL	17.1353 mL
10 mM	0.1714 mL	0.8568 mL	1.7135 mL	8.5677 mL
20 mM	0.0857 mL	0.4284 mL	0.8568 mL	4.2838 mL
50 mM	0.0343 mL	0.1714 mL	0.3427 mL	1.7135 mL