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Gomisin N

Name: Gomisin N
Brand: TargetMol
SKU: T8297
Price: 198 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.97%

货号 T8297Cas号 69176-52-9

别名 戈米辛N

Gomisin N 是从五味子中分离得到的一种天然产物，有镇静和催眠生物活性。它具有用于治疗过敏和抑制癌症增殖和诱导细胞凋亡的潜力。

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Gomisin N

一键复制产品信息

很棒

纯度: 99.97%

货号 T8297 别名 戈米辛NCas号 69176-52-9

Gomisin N 是从五味子中分离得到的一种天然产物，有镇静和催眠生物活性。它具有用于治疗过敏和抑制癌症增殖和诱导细胞凋亡的潜力。

规格	价格	库存
1 mg	¥ 198	现货
5 mg	¥ 496	现货
10 mg	¥ 795	现货
25 mg	¥ 1,330	现货
50 mg	¥ 1,970	现货
100 mg	¥ 2,930	现货
500 mg	¥ 6,630	待询
1 mL x 10 mM (in DMSO)	¥ 437	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.97%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Gomisin N AI Summary

Gomisin N exhibits diverse bioactivities, including antiproliferative effects on various human cell lines (SNU638, T47D, HCT15, K562, A549) with varying IC50 values after 72 hours of exposure. It demonstrates cytotoxicity against human HL60 cells (IC50: 52400.0 nM) and potentiates doxorubicin-induced cytotoxicity in HL60/MDR cells while inhibiting P-gp-mediated doxorubicin efflux and causing cell cycle arrest at various phases. The compound also exhibits hepatoprotective activity against carbon tetrachloride-induced toxicity in human HL-7702 cells, enhancing cell survival by 42.8% at 0.2 ug/ul concentration. It inhibits the Wnt/beta-catenin signaling pathway in HEK293 cells with a -17.8% inhibition at 20 uM after 24 hours, and shows inhibitory activity against electric eel AChE (-4.27%) and horse BChE (12.72%). Additionally, it demonstrates antineuroinflammatory activity by reducing nitric oxide production in LPS-stimulated mouse BV2 cells (IC50 >100,000.0 nM) and significantly inhibits human recombinant GSK3-beta with an IC50 of 73.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Gomisin N, isolated from Schisandra chinensis, produces beneficial sedative and hypnotic bioactivity. It has the potential for use in the treatment of allergy and inhibits proliferation and induces apoptosis in cancer.
别名	戈米辛N

化学信息

分子量	400.46
分子式	C₂₃H₂₈O₆
CAS No.	69176-52-9
Smiles	COc1cc2C[C@@H](C)[C@@H](C)Cc3cc4OCOc4c(OC)c3-c2c(OC)c1OC
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 22.5 mg/mL (56.19 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.99 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4971 mL	12.4856 mL	24.9713 mL	124.8564 mL
5 mM	0.4994 mL	2.4971 mL	4.9943 mL	24.9713 mL
10 mM	0.2497 mL	1.2486 mL	2.4971 mL	12.4856 mL
20 mM	0.1249 mL	0.6243 mL	1.2486 mL	6.2428 mL
50 mM	0.0499 mL	0.2497 mL	0.4994 mL	2.4971 mL