规格

价格

库存

数量

1 mg

¥ 185

现货

5 mg

¥ 397

现货

10 mg

¥ 583

现货

25 mg

¥ 980

现货

50 mg

¥ 1,490

现货

100 mg

¥ 2,230

现货

500 mg

¥ 5,660

5日内发货

1 g

¥ 7,880

5日内发货

生物活性

产品描述	Zerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger Z. zerumbet.It has also been shown to have anti-oxidant and anti-inflammatory activities, contributing to immunomodulatory and hepatoprotective effects.
体内活性	预处理zerumbone不仅减少了白细胞渗透到肺泡空间，也抑制了LPS引起的急性肺损伤(ALI)中的肺水肿。LPS导致的促炎细胞因子如TNFα和IL-6的分泌减少被zerumbone逆转。LPS诱导的促炎介质iNOS和COX-2的表达也被zerumbone抑制。此外，zerumbone还抑制了LPS引发的ALI中NFκB激活和Akt磷酸化。表明zerumbone对内毒素引发的ALI的保护机制是通过抑制Akt-NFκB激活。
动物实验	Mice were pretreated with zerumbone at various concentrations for 30 min followed by intratracheal administration of LPS for 6 h.Pretreatment with zerumbone not only reduced leukocytes infiltration into the alveolar space but also inhibited lung edema in LPS-induced ALI. Decreased secretion of proinflammatory cytokines such as TNFα and IL-6 caused by LPS were reversed by zerumbone.
别名	球姜酮, 花薑酮

化学信息

分子量	218.33
分子式	C₁₅H₂₂O
CAS No.	471-05-6
Smiles	C\C1=C/CC(C)(C)\C=C\C(=O)\C(C)=C\CC1
密度	0.887 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 237.5 mg/mL (1087.8 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.16 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5802 mL	22.9011 mL	45.8022 mL	229.0111 mL
5 mM	0.9160 mL	4.5802 mL	9.1604 mL	45.8022 mL
10 mM	0.4580 mL	2.2901 mL	4.5802 mL	22.9011 mL
20 mM	0.2290 mL	1.1451 mL	2.2901 mL	11.4506 mL
50 mM	0.0916 mL	0.4580 mL	0.9160 mL	4.5802 mL
100 mM	0.0458 mL	0.2290 mL	0.4580 mL	2.2901 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

zerumbone

zerumbone

产品介绍

引用文献

计算器

体内实验配液计算器

剂量转换

关键词

zerumbone

zerumbone

zerumbone 相关产品

产品介绍

引用文献

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体内实验配液计算器

剂量转换

关键词