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Anti-IL10 Monoclonal Antibody
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还可以产品编号 TMAZ-0029
别名 Interleukin-10, Cytokine synthesis inhibitory factor
Anti-IL10 Monoclonal Antibody is a humanized rabbit antibody targeting IL10. Anti-IL10 Monoclonal Antibody can be used in ELISA, FCM, IF. 可用于 ELISA,FCM,IF。
Anti-IL10 Monoclonal Antibody
Anti-IL10 Monoclonal Antibody
一键复制产品信息 还可以产品编号 TMAZ-0029 别名 Interleukin-10, Cytokine synthesis inhibitory factor
Anti-IL10 Monoclonal Antibody is a humanized rabbit antibody targeting IL10. Anti-IL10 Monoclonal Antibody can be used in ELISA, FCM, IF. 可用于 ELISA,FCM,IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 1,250 | 7日内发货 | |
| 50 μg | ¥ 1,500 | 7日内发货 | |
| 100 μg | ¥ 2,099 | 7日内发货 |
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| 产品描述 | Anti-IL10 Monoclonal Antibody is a humanized rabbit antibody targeting IL10. Anti-IL10 Monoclonal Antibody can be used in ELISA,FCM,IF. |
| 别名 | Interleukin-10, Cytokine synthesis inhibitory factor |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of IL10 overexpressed 353F cells with TMAZ-0029, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | ELISAFCMIF |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FCM; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Single-pass type I membrane |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of IL10 protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in PBS. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed: 16982608). In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators (PubMed: 18025162). Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha (PubMed: 11564774, PubMed: 1940799, PubMed: 7512027). Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (PubMed: 8144879). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity) |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Biotin |
| 可提供抗体种类 | 2 |
| 免疫原 | IL10 |
| 抗原种属 | Human |
| 基因ID | |
| Uniprot ID | |
| 研究领域 | Immunology Research |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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