Clopamide

Name: Clopamide
Brand: TargetMol
SKU: T6086
Rating: 4.5 (1 reviews)

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很棒

纯度: 99.71%

货号 T6086Cas号 636-54-4

别名 氯帕胺, Brinaldix, Aquex, Adurix

Clopamide (Brinaldix) 是口服有效的噻嗪类利尿剂，对钠耦合的氯离子共转运蛋白 SLC12A3有抑制作用。Clopamide 在高血压和心力衰竭中具有研究价值。

Clopamide

一键复制产品信息

很棒

纯度: 99.71%

货号 T6086 别名 氯帕胺, Brinaldix, Aquex, AdurixCas号 636-54-4

Clopamide (Brinaldix) 是口服有效的噻嗪类利尿剂，对钠耦合的氯离子共转运蛋白 SLC12A3有抑制作用。Clopamide 在高血压和心力衰竭中具有研究价值。

规格	价格	库存
25 mg	¥ 296	4-6周
50 mg	¥ 417	4-6周
100 mg	¥ 671	4-6周
1 mL x 10 mM (in DMSO)	¥ 195	现货

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产品介绍

Clopamide AI Summary

Clopamide exhibits a range of bioactivities with varying potencies across multiple targets. It shows moderate potency (316.2 nM) in altering Lamin A splicing and a higher potency as an inhibitor of HSD17B4 (19952.6 nM). The compound also exhibits moderate potencies in inducing genomic imprint erasure (5011.9 nM), inhibiting chronic active B-cell receptor signaling (5804.8 nM), and inhibiting cell surface uPA generation (8912.5 nM). It demonstrates good potency (585.8 nM) as a delayed death inhibitor of the malarial parasite plastid after 96 hours of incubation and notable potency (1000.0 nM) in inducing DNA re-replication in SW480 colon adenocarcinoma cells. Additionally, it shows moderate potency (6309.6 nM) as an inhibitor of TDP-43. The compound displays low bioactivity in inhibiting the cell viability of Vero E6 cells infected with SARS-CoV-2, with an inhibition index of 0.2254, suggesting limited effectiveness compared to the control. It exhibits weak antiviral activity against SARS-CoV-2 in VERO-6 cells with an IC50 value greater than 20000.0 nM. In terms of HDAC6 inhibition, the compound shows a 10.39% inhibition rate using a commercial peptide substrate but -4.01% using a custom peptide substrate. Further assessments indicate that Clopamide demonstrated no significant bioactivity in various assays, showing AC50 values greater than 30000.0 nM across different targets such as ion channels, neurotransmitter receptors, enzymes, and nuclear receptors, and it did not exhibit significant agonist or antagonist effects in the tested in vitro assays..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Clopamide (Brinaldix) is a piperidine and sulfamoylbenzamide-based diuretic with thiazide-like diuretic activity.
别名	氯帕胺, Brinaldix, Aquex, Adurix

化学信息

分子量	345.84
分子式	C₁₄H₂₀ClN₃O₃S
CAS No.	636-54-4
Smiles	CC1CCCC(C)N1NC(=O)c1ccc(Cl)c(c1)S(N)(=O)=O
密度	1.39 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 25 mg/mL (72.29 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.78 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8915 mL	14.4576 mL	28.9151 mL	144.5755 mL
5 mM	0.5783 mL	2.8915 mL	5.7830 mL	28.9151 mL
10 mM	0.2892 mL	1.4458 mL	2.8915 mL	14.4576 mL
20 mM	0.1446 mL	0.7229 mL	1.4458 mL	7.2288 mL
50 mM	0.0578 mL	0.2892 mL	0.5783 mL	2.8915 mL