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LDHA-IN-4

Name: LDHA-IN-4
Brand: TargetMol
SKU: T3175
Price: 342 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.68%

货号 T3175Cas号 1370290-34-8

别名 LDHA Inhibitor, AZ-33, AZ33, AZ 33

LDHA-IN-4 (AZ33) 是乳酸脱氢酶 A 选择性抑制剂，IC50=0.5 μM，Kd=0.093 μM。

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LDHA-IN-4

一键复制产品信息

很棒

纯度: 99.68%

货号 T3175 别名 LDHA Inhibitor, AZ-33, AZ33, AZ 33Cas号 1370290-34-8

LDHA-IN-4 (AZ33) 是乳酸脱氢酶 A 选择性抑制剂，IC50=0.5 μM，Kd=0.093 μM。

规格	价格	库存
1 mg	¥ 342	现货
5 mg	¥ 1,330	现货
10 mg	¥ 2,160	现货
25 mg	¥ 3,890	现货
50 mg	¥ 5,570	现货
100 mg	¥ 7,690	待询

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.68%

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COA HPLC HNMR 产品操作手册

产品介绍

LDHA-IN-4 AI Summary

LDHA-IN-4 shows binding affinity to 6-His-tagged human LDHA, with a Kd value of 93.0 nM, and inhibits full-length human recombinant LDHA with an IC50 value of 500.0 nM when using sodium pyruvate as a substrate after 10 minutes. In addition to LDHA, LDHA-IN-4 exhibits inhibitory activity against several enzymes involved in cellular metabolism, such as lactate dehydrogenase (LDH) isoforms and malate dehydrogenase (MDH), demonstrating IC50 values ranging from 920.0 nM to over 57,000.0 nM. The compound also shows cytotoxicity against human A673 and MIAPaCa2 cells in long-term inhibition assays with IC50 values greater than 20,000.0 nM. Moreover, it stabilizes LDHA in cellular lysates with an EC50 value of 1600.0 nM, suggesting potential modulation of enzyme activity under certain conditions. These results indicate that LDHA-IN-4 has potential bioactivity and therapeutic implications in targeting LDHA and other metabolic enzymes..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	LDHA-IN-4 (AZ33) is an LDHA inhibitor. Binding affinity to 6-His-tagged human LDHA (2 to 322 amino acid residue) expressed in Escherichia coli BL21 (DE3) cells by SPR analysis with an active value of 0.093 μM.
别名	LDHA Inhibitor, AZ-33, AZ33, AZ 33

化学信息

分子量	497.56
分子式	C₂₅H₂₇N₃O₆S
CAS No.	1370290-34-8
Smiles	Cc1nc2ccc(NC(=O)CCNC(=O)CCCc3ccc(CC(C(O)=O)C(O)=O)cc3)cc2s1
密度	1.381 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 4.98 mg/mL (10.01 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0098 mL	10.0490 mL	20.0981 mL	100.4904 mL
5 mM	0.4020 mL	2.0098 mL	4.0196 mL	20.0981 mL
10 mM	0.2010 mL	1.0049 mL	2.0098 mL	10.0490 mL

计算器

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稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。