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NSC-60339
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很棒纯度: 98.78%
货号 T16349Cas号 70-09-7
NSC-60339 是一种外排泵抑制剂和 AcrAB-TolC 的底物，是聚对苯二甲酸衍生物，对癌症化疗有潜在作用。
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NSC-60339
一键复制产品信息 很棒纯度: 98.78%
货号 T16349Cas号 70-09-7
NSC-60339 是一种外排泵抑制剂和 AcrAB-TolC 的底物，是聚对苯二甲酸衍生物，对癌症化疗有潜在作用。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 642 | 现货 | |
| 5 mg | ¥ 1,590 | 现货 | |
| 10 mg | ¥ 2,330 | 现货 | |
| 25 mg | ¥ 3,690 | 现货 | |
| 50 mg | ¥ 4,970 | 现货 | |
| 100 mg | ¥ 6,530 | 现货 | |
| 200 mg | ¥ 8,790 | 现货 |
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产品介绍
NSC-60339 AI Summary
NSC-60339 exhibits a wide range of bioactivities, including potent inhibitory effects against multiple biological targets. These targets include MLL CXXC domain-DNA interaction, ALDH1A1, lipid storage modulators in Drosophila S3 cells, Influenza NS1 protein function, DNA Polymerase Beta, N370S glucocerebrosidase, JMJD2A-Tudor Domain, UBC13 Polyubiquitin, T. brucei phosphofructokinase, chronic active B-Cell receptor signaling, the phosphatase activity of Eya2, Histone Lysine Methyltransferase G9a, Rango-Importin beta complex formation, HP1-beta chromodomain interactions with methylated histone tails, Human Flap endonuclease 1 (FEN1), Polymerase Iota, Polymerase Kappa, and human tyrosyl-DNA phosphodiesterase 1 (TDP1). It also affects the growth of Candida albicans, exerts delayed death inhibition on malarial parasite plastids, and interacts with the oncogenic and cytokinetic protein MgcRacGAP, RAD54, SUMO1-mediated protein-protein interactions, WRN Helicase, and the HIV-1 protein Vpr.
NSC-60339 stabilizes DNA duplex hairpin structures and human G-quadruplex F21T by moderately increasing their melting temperatures. The compound also shows potent antimicrobial activity against Escherichia coli, targeting strains with specific mutations or deletions linked to membrane integrity and efflux pump systems. It exhibits varying MIC values from >200000.0 nM to 12500.0 nM and inhibits the AcrA efflux pump, enhancing novobiocin-induced antibacterial activity and impacting bacterial membrane permeability and HT dye uptake.
However, despite its broad biological activity, NSC-60339 exhibits no significant antibacterial, antifungal, or cytotoxic effects in other tested strains or cells, with MIC and cytotoxic concentration (CC50) values exceeding 10000.0 nM in respective assays..
Note: Summary generated by AI. Data source: ChEMBL 
生物活性
化学信息
储存&溶解度
| 产品描述 | NSC-60339 is an inhibitor of efflux pump, and a substrate of AcrAB-TolC, is a polybasic terephthalic acid derivative studied as a potential cancer chemotherapeutic agent. |
| 分子量 | 486.95 |
| 分子式 | C26H23ClN6O2 |
| CAS No. | 70-09-7 |
| Smiles | Clc1cc(ccc1C(=O)Nc1ccc(cc1)C1=NCCN1)C(=O)Nc1ccc(cc1)C1=NCCN1 |
| 密度 | no data available |
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| 溶解度信息 | DMSO: 4.5 mg/mL (9.24 mM), Sonication is recommended. | |||||||||||||||
溶液配制表 | ||||||||||||||||
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计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， 一共给药动物10只，您使用的配方为5%
DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。 以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
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