2-Hydroxyisobutyric acid (α-Hydroxyisobutyric acid) is a metabolite of methyl tert-butyl ether (MTBE). MTBE may be obtained through environmental exposure. MTBE is rapidly eliminated from the body, mainly through expired air as the unchanged compound. MTBE is to some extent metabolised to t-butyl alcohol (TBA) and formaldehyde and oxidised to 2-methyl-1,2-propanediol and a-hydroxy isobuturic acid. 2-Hydroxyisobutyric acid has been used as an arial bactericide.

甘油可在大鼠模型中诱发急性肾衰竭。由甘油或硝酸铀诱发的急性肾衰竭能降低某些化合物的肝胆转运，调节药物进入中枢神经系统的分布，并影响多种肝微粒体酶的活性。