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Eliprodil

Name: Eliprodil
Brand: TargetMol
SKU: T1751
Price: 128 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 依利罗地, SL-820715

货号 T1751Cas号 119431-25-3 一键复制产品信息纯度: 99.77%

很棒

Eliprodil (SL-820715) 是NR2B-NMDA 受体高效选择性抑制剂，IC50值1uM。它对NR2A-和NR2C-NMDA 受体作用较弱，可用于研究帕金森病和运动障碍治疗的试验。

Eliprodil

一键复制产品信息

很棒

纯度: 99.77%

货号 T1751Cas号 119431-25-3

别名 依利罗地, SL-820715

Eliprodil (SL-820715) 是NR2B-NMDA 受体高效选择性抑制剂，IC50值1uM。它对NR2A-和NR2C-NMDA 受体作用较弱，可用于研究帕金森病和运动障碍治疗的试验。

规格	价格	库存
5 mg	¥ 162	现货
10 mg	¥ 269	现货
25 mg	¥ 535	现货
50 mg	¥ 833	现货
100 mg	¥ 1,290	现货
500 mg	¥ 2,930	现货
1 mL x 10 mM (in DMSO)	¥ 128	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.77%

颜色: 白色

资源下载: COA HNMR HPLC产品操作手册

产品介绍

Eliprodil AI Summary

Eliprodil exhibits a range of bioactivities across different biological pathways and receptors. It demonstrates potent competitive antagonist activity at the GluN2B subunit of the NMDA receptor, with a high affinity indicated by a Ki value of 13.0 nM, effectively displacing [3H]ifenprodil. It also shows inhibitory activity against the NMDA responses at NR1A/2B receptors with an IC50 of 1400.0 nM, and exhibits affinity for the alpha-1 adrenergic receptor with an IC50 of 3300.0 nM. In addition, it inhibits voltage-gated K+ currents by 67.0% at 10 µM concentration and has an ED50 of 1.0 mg/kg in the mouse electric shock assay. Additionally, it shows neuroprotective effects in a rat model of focal cerebral ischemia by reducing infarct volume when administered intravenously at 1 mg/kg. Eliprodil also displays antiplasmodial activity against Plasmodium falciparum with IC50 values ranging from 251.19 nM to 2511.89 nM. Furthermore, it shows potential antiviral activity against SARS-CoV-2, inhibiting virus-induced cytotoxicity of VERO-6 cells, although with IC50 values greater than 20000.0 nM. Its diverse range of bioactivities, including modulation of glutamatergic neurotransmission and potential pharmacological effects on various receptors, suggests its importance in therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Eliprodil (SL-820715)(SL-820715), a non-competitive NR2B-NMDA receptor antagonist(IC50: 1 uM), less effective for NR2A- and NR2C-containing receptors(IC50> 100 uM). It has been used in trials studying the treatment of Parkinson Disease and Movement Disorders.
靶点活性	NR2B-NMDA:1 μM
别名	依利罗地, SL-820715

化学信息

分子量	347.85
分子式	C₂₀H₂₃ClFNO
CAS No.	119431-25-3
Smiles	OC(CN1CCC(Cc2ccc(F)cc2)CC1)c1ccc(Cl)cc1
密度	1.205 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 6 mg/mL (17.25 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8748 mL	14.3740 mL	28.7480 mL	143.7401 mL
5 mM	0.5750 mL	2.8748 mL	5.7496 mL	28.7480 mL
10 mM	0.2875 mL	1.4374 mL	2.8748 mL	14.3740 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。