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BCTC

Name: BCTC
Brand: TargetMol
SKU: T7102
Price: 129 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺

货号 T7102Cas号 393514-24-4 一键复制产品信息纯度: 99.74%

很棒

BCTC 是有效的、特异性的瞬时受体阳离子通道M8(TRPM8)抑制剂。

BCTC

一键复制产品信息

很棒

纯度: 99.74%

货号 T7102Cas号 393514-24-4

别名 N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺

BCTC 是有效的、特异性的瞬时受体阳离子通道M8(TRPM8)抑制剂。

为众多的药物研发团队赋能，

让新药发现更简单！

规格	价格	库存
1 mg	¥ 129	现货
5 mg	¥ 292	现货
10 mg	¥ 393	现货
25 mg	¥ 756	现货
50 mg	¥ 1,380	现货
100 mg	¥ 2,070	现货
200 mg	¥ 2,950	现货
1 mL x 10 mM (in DMSO)	¥ 328	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.74%

颜色: 白色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

BCTC AI Summary

BCTC exhibits significant antagonist activity at both human and rodent TRPV1 receptors, effectively inhibiting capsaicin-induced, low pH-induced, and temperature-induced activation with IC50 values ranging from 0.18 nM to 34.9 nM. It also shows potent inhibitory effects on TRPM8-mediated calcium influx with IC50 values between 350.0 nM and 800.0 nM. Pharmacokinetic studies in rats reveal a volume of distribution (Vz) of 5.8 L.kg⁻¹, plasma clearance (CL) of 76.67 mL.min⁻¹.kg⁻¹, and a half-life (T1/2) of 0.9 hours for intravenous administration. Oral bioavailability is reported at 10.0% to 15.1% at doses of 30-40 mg/kg, with a peak plasma concentration (Cmax) of 2992.76 nM achieved in 0.5 hours post-administration. Additionally, BCTC inhibits the hERG channel significantly (87.0%) but has limited metabolic stability in rat liver (0.3% remaining). It also demonstrates antiviral properties, inhibiting SARS-CoV-2 cytotoxicity in specific cell lines, although efficacy varies. The compound's solubility is reported to be between 600.0 to 620.0 µg/mL. BCTC's diverse bioactivities suggest its potential in therapeutic research targeting TRPV1/TRPM8 related conditions and viral infections..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	BCTC is a potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 (IC50 of 35 and 6 nM, respectively)
别名	N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺

化学信息

分子量	372.89
分子式	C₂₀H₂₅ClN₄O
CAS No.	393514-24-4
Smiles	CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2Cl)cc1
密度	1.229 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 50 mg/mL (134.09 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6818 mL	13.4088 mL	26.8176 mL	134.0878 mL
5 mM	0.5364 mL	2.6818 mL	5.3635 mL	26.8176 mL
10 mM	0.2682 mL	1.3409 mL	2.6818 mL	13.4088 mL
20 mM	0.1341 mL	0.6704 mL	1.3409 mL	6.7044 mL
50 mM	0.0536 mL	0.2682 mL	0.5364 mL	2.6818 mL
100 mM	0.0268 mL	0.1341 mL	0.2682 mL	1.3409 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。