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Pinacidil

Name: Pinacidil
Brand: TargetMol
SKU: T12478L
Price: 197 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.9%

货号 T12478LCas号 60560-33-0

别名 吡那地尔, S-1230, S 1230, P-1134, P1134, P 1134

Pinacidil (P 1134) 是钾通道的有效激活剂。Pinacidil 通过打开 K+-通道使血管平滑肌超极化，显示出抗高血压活性。它显著改善再灌注功能和心脏顺应性。它具有直接的心脏保护作用。

Pinacidil

一键复制产品信息

很棒

纯度: 99.9%

货号 T12478L 别名 吡那地尔, S-1230, S 1230, P-1134, P1134, P 1134Cas号 60560-33-0

规格	价格	库存
1 mg	¥ 197	现货
5 mg	¥ 417	现货
10 mg	¥ 587	现货
25 mg	¥ 997	现货
50 mg	¥ 1,685	现货
100 mg	¥ 2,530	现货
1 mL x 10 mM (in DMSO)	¥ 460	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.9%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Pinacidil AI Summary

Pinacidil exhibits a range of bioactivities relating to muscle relaxation, insulin secretion, and cardiovascular effects. It has potent vasorelaxant properties, with an EC50 of 724.44 nM and high intrinsic activity of 91.9% in relaxing rat aorta precontracted with KCl. Additionally, it inhibits the contraction of rat detrusor strips with an IC50 of 630.0 nM and demonstrates significant relaxant activities in various smooth muscles, including the rat aorta and guinea pig trachea. In terms of insulin secretion, Pinacidil inhibits glucose-stimulated insulin release from rat islets, with an IC50 value greater than 100,000 nM. It also demonstrates inhibitory activity in specific cellular assays, such as inhibiting ATP-dependent taurocholate uptake in human BSEP with an IC50 of 348,100 nM. Pinacidil shows antihypertensive effects in animal models, including significant reductions in blood pressure in spontaneously hypertensive rats and hypertensive dogs. It demonstrates efficacy in various vasorelaxant and potassium channel activities, suggesting potential therapeutic benefits in cardiovascular treatments. Additionally, the compound exhibits selective bioactivities related to its interaction with potassium channels, showing a significant effect on ATP-sensitive potassium channels (KATP) in different smooth muscle and pancreatic islet cells. Overall, Pinacidil presents a promising profile as a vasorelaxant and antihypertensive agent, while also affecting glucose-induced insulin secretion and demonstrating significant interaction with potassium channels..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Pinacidil (P 1134) is a guanidine that opens potassium channels and directly dilates peripheral blood vessels in small arteries, lowering blood pressure and peripheral resistance and producing fluid retention.
别名	吡那地尔, S-1230, S 1230, P-1134, P1134, P 1134

化学信息

分子量	245.32
分子式	C₁₃H₁₉N₅
CAS No.	60560-33-0
Smiles	CC(N\C(Nc1ccncc1)=N/C#N)C(C)(C)C
密度	1.1402 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 100 mg/mL (407.63 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (16.31 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0763 mL	20.3815 mL	40.7631 mL	203.8154 mL
5 mM	0.8153 mL	4.0763 mL	8.1526 mL	40.7631 mL
10 mM	0.4076 mL	2.0382 mL	4.0763 mL	20.3815 mL
20 mM	0.2038 mL	1.0191 mL	2.0382 mL	10.1908 mL
50 mM	0.0815 mL	0.4076 mL	0.8153 mL	4.0763 mL
100 mM	0.0408 mL	0.2038 mL	0.4076 mL	2.0382 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

S1230 reperfusion PotassiumChannel Potassium Channel Pinacidil KcsA Inhibitor inhibit cardioprotective cardiac compliance antihypertensive

Pinacidil

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