DGAT-1 inhibitor 2

Name: DGAT-1 inhibitor 2
Brand: TargetMol
SKU: T11016
Price: 477 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 98.36%

货号 T11016Cas号 942999-61-3

DGAT-1 inhibitor 2是有效的DGAT-1抑制剂，具有减肥功效。

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DGAT-1 inhibitor 2

一键复制产品信息

很棒

纯度: 98.36%

货号 T11016Cas号 942999-61-3

DGAT-1 inhibitor 2是有效的DGAT-1抑制剂，具有减肥功效。

规格	价格	库存
1 mg	¥ 477	现货
2 mg	¥ 695	现货
5 mg	¥ 1,160	现货
10 mg	¥ 1,850	现货
25 mg	¥ 3,430	现货
50 mg	¥ 5,180	现货
100 mg	¥ 7,130	现货
1 mL x 10 mM (in DMSO)	¥ 1,270	现货

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产品介绍

DGAT-1 inhibitor 2 AI Summary

DGAT-1 inhibitor 2 exhibits diverse bioactivities relevant to lipid metabolism. It demonstrates species-specific metabolic stability in hepatocytes and alamethicin-activated microsomes, with varying conversion levels to its acyl glucuronide form. At a concentration of 30 µM, it inhibits the cytochrome P450 enzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 by less than 25%. It effectively inhibits DGAT1 and triacylglycerol synthesis, as evidenced by its IC50 values across various assays. The compound displays different plasma clearance rates, volumes of distribution, half-lives, and bioavailabilities across species and administration routes. It has moderate lipophilicity, aqueous solubility, and plasma protein binding, along with demonstrated permeability in both directions in MDCK cells. Notably, it reduces plasma triacylglycerol levels and adipose triacylglycerol synthesis in a dose-dependent manner in rat models. Given these properties, DGAT-1 inhibitor 2 holds promise for therapeutic applications targeting fat metabolism and triglyceride synthesis..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述

DGAT-1 inhibitor 2 is an effective DGAT-1 inhibitor; anti-obesity drug. Objective: DGAT-1 acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) is one of two known DGAT enzymes that catalyze the final step of triglyceride synthesis. The discovery of transgenic mice and pharmacological studies indicate that inhibiting DGAT1 is a promising strategy for treating obesity and type 2 diabetes.

化学信息

分子量	420.5
分子式	C₂₄H₂₈N₄O₃
CAS No.	942999-61-3
Smiles	CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)C12CCC(CC(O)=O)(CC1)CC2
密度	1.39 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 12 mg/mL (28.54 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3781 mL	11.8906 mL	23.7812 mL	118.9061 mL
5 mM	0.4756 mL	2.3781 mL	4.7562 mL	23.7812 mL
10 mM	0.2378 mL	1.1891 mL	2.3781 mL	11.8906 mL
20 mM	0.1189 mL	0.5945 mL	1.1891 mL	5.9453 mL