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PF-9601N

Name: PF-9601N
Brand: TargetMol
SKU: T8849
Price: 177 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.29%

货号 T8849Cas号 133845-63-3

PF-9601N 是一种单胺氧化酶 B (MAO-B) 抑制剂，在多种体内外模型中表现出抗帕金森病 (PD) 的神经保护作用。它可用于研究兴奋性毒性介导的神经退行性疾病。

为众多的药物研发团队赋能，

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PF-9601N

一键复制产品信息

很棒

纯度: 98.29%

货号 T8849Cas号 133845-63-3

规格	价格	库存
1 mg	¥ 177	现货
5 mg	¥ 448	现货
10 mg	¥ 708	现货
25 mg	¥ 1,490	现货
50 mg	¥ 2,350	现货
100 mg	¥ 3,330	现货
200 mg	¥ 4,680	现货
1 mL x 10 mM (in DMSO)	¥ 415	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

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纯度: 98.29%

颜色: 黄色

性状: Solid

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资源下载:

COA HNMR HPLC LCMS 产品操作手册

产品介绍

PF-9601N AI Summary

PF-9601N exhibits significant bioactivity as a monoamine oxidase (MAO) inhibitor, targeting both MAO-A and MAO-B enzymes. For human MAO-A, it shows an IC50 value of 287.3 nM, while for human MAO-B, it has a much lower IC50 value of 4.1 nM, indicating higher potency and selectivity towards MAO-B. Similarly, for rat enzymes, it displays IC50 values of 1250.0 nM for MAO-A and 22.0 nM for MAO-B. The Ki values for Monoamine oxidase B are 794.33 nM and as low as 0.75 nM, further underscoring its strong inhibitory effect, whereas the Ki values for Monoamine oxidase A span 790.0 nM. This compound does not show significant activity against acetylcholinesterase and butyrylcholinesterase, with IC50 values exceeding 100,000.0 nM. The inhibition profile of PF-9601N suggests that it has potential therapeutic implications for conditions associated with MAO-B, such as neurodegenerative diseases, by modulating neurotransmitter levels like serotonin and phenylethylamine..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	PF-9601N showed high potency and selectivity as a MAO-BI (monoamine oxidase type B inhibitor) and also demonstrated remarkable neuroprotective properties in several in vivo and cellular models of PD.

化学信息

分子量	290.36
分子式	C₁₉H₁₈N₂O
CAS No.	133845-63-3
Smiles	C#CCNCc1cc2cc(OCc3ccccc3)ccc2[nH]1
密度	1.185 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 25 mg/mL (86.1 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4440 mL	17.2200 mL	34.4400 mL	172.2000 mL
5 mM	0.6888 mL	3.4440 mL	6.8880 mL	34.4400 mL
10 mM	0.3444 mL	1.7220 mL	3.4440 mL	17.2200 mL
20 mM	0.1722 mL	0.8610 mL	1.7220 mL	8.6100 mL
50 mM	0.0689 mL	0.3444 mL	0.6888 mL	3.4440 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。