规格

价格

库存

数量

1 mg

¥ 1,650

现货

5 mg

¥ 4,130

现货

10 mg

¥ 5,880

现货

25 mg

¥ 8,750

现货

50 mg

¥ 11,800

现货

100 mg

¥ 15,900

现货

1 mL x 10 mM (in DMSO)

¥ 3,780

现货

生物活性

产品描述	SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3, 420 times for Tyk2).
体外活性	SHR0302 (1nM-10μM) exerted an inhibitory effect on the activation, proliferation and migration of hepatic stellate cells (HSCs). SHR0302 induced the apoptosis of HSCs. The pharmacological inhibition of the JAK1/signal transducer and activator of transcription (STAT)3 pathway led to the disruption of functions essential for HSC[1].
体内活性	SHR0302 may attenuate the severity of AA rats, partially through reducing Th17 function and total B cell proportion by inhibiting JAK1-STAT3 phosphorylation[2].
别名	ARQ252

化学信息

分子量	414.48
分子式	C₁₈H₂₂N₈O₂S
CAS No.	1445987-21-2
Smiles	[H][C@@]12C[C@H](C[C@]1([H])CN(C2)C(=O)Nc1nc(OC)ns1)N(C)c1ncnc2[nH]ccc12
密度	1.507 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 30 mg/mL (72.38 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (4.83 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO