SKF-86002

Name: SKF-86002
Brand: TargetMol
SKU: T2367
Price: 138 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.85%

货号 T2367Cas号 72873-74-6

别名 SKF86002

SKF-86002 是一种可口服的 p38 MAPK 抑制剂，具有抗炎和抗关节炎活性，可用于缓解疼痛的研究。它能抑制脂氧合酶和环氧合酶介导的花生四烯酸代谢，还抑制脂多糖 (LPS) 刺激人单核细胞产生 IL-1 和 TNF-α，IC50为 1 μM。

SKF-86002

一键复制产品信息

很棒

纯度: 99.85%

货号 T2367 别名 SKF86002Cas号 72873-74-6

规格	价格	库存
2 mg	¥ 138	现货
5 mg	¥ 276	现货
10 mg	¥ 415	现货
25 mg	¥ 697	现货
50 mg	¥ 1,030	现货
100 mg	¥ 1,530	现货
200 mg	¥ 2,070	现货

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产品介绍

SKF-86002 AI Summary

SKF-86002 demonstrates significant inhibitory activity against several targets, including p38 alpha mitogen-activated protein kinase (MAPK) with an IC50 value of 400.0 nM, and in other bioassays with various IC50 values. It shows efficacy in in vivo models, such as adjuvant-induced arthritis in rats, significantly reducing inflammation at a dose of 50 mg/kg when administered orally. Additionally, it stimulates the right hind paw in a cutaneous oxazolone-induced contact sensitivity mouse model at a dose of 25 mg/kg. In human whole blood and peripheral blood mononuclear cells, SKF-86002 inhibits TNF-alpha and IL1-beta release with IC50 values ranging from 520.0 nM to 27000.0 nM. Furthermore, it inhibits other enzymes and pathways, including Prostaglandin H2 synthase 1 (PGHS-1) with an IC50 of 5400.0 nM and 5-lipoxygenase in rat RBL-1 cells with an IC50 of 10000.0 nM. It also inhibits the CSBP kinase in human THP-1 cells, Yes1 kinase, Marburg virus entry, and shows some activity against O. lienalis microfilariae. Despite its wide range of bioactivities, the compound displays low cytotoxicity against Rhesus Monkey LLCMK2 cells and has marginal activity against HDAC6 enzyme. Overall, SKF-86002 appears to have promising anti-inflammatory properties with potential therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).
靶点活性	p38 MAPk:0.5-1 μM, IL-1:1 μM, TNF-α:1 μM
别名	SKF86002

化学信息

分子量	297.35
分子式	C₁₆H₁₂FN₃S
CAS No.	72873-74-6
Smiles	Fc1ccc(cc1)-c1nc2SCCn2c1-c1ccncc1
密度	1.39 g/cm3 (Predicted)
颜色	Yellow
物理性状	Solid

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度信息	DMSO: Slightly soluble