Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FAK-IN-4 (Compound 7d) 具有抗癌活性,可以诱导细胞凋亡。FAK-IN-4 是FAK 的潜在抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 10-14周 | ||
50 mg | ¥ 13,800 | 10-14周 | ||
100 mg | ¥ 17,500 | 10-14周 |
产品描述 | FAK-IN-4 (Compound 7d) has anticancer activities that can induce cell apoptosis. FAK-IN-4 is potential inhibitor of FAK [1]. |
体外活性 | FAK-IN-4 (Compound 7d) (0-200 μM, 72 h) shows antiproliferative activity against triple-negative breast cancer (TNBC) cells [1]. FAK-IN-4 (0-20 μM, 24 h) inhibits cell invasion and migration of MDA-MB-231 cells [1]. FAK-IN-4 (0-20 μM, 72 h) causes dose-dependent Y925 dephosphorylation of FAK, and induces apoptosis in MDA-MB-231 cells [1]. FAK-IN-4 inhibits the formation of focal adhesions (FAs) and stress fibers (SFs) in MDA-MB-231 cells [1]. Cell Proliferation Assay [1] Cell Line: MDA-MB-231, MDA-MB-157, MDA-MB-453 and MCF10A Concentration: 0.78, 1.56, 3.13, 5, 6.25, 100, 12.5, 25, 50, 100 and 200 μM Incubation Time: 72 h Result: Inhibited the growth of TNBC cells with IC 50 values of 8.37, 12.09, 9.07 and 40.63 μM against MDA-MB-231, MDA-MB-157, MDA-MB-453 and MCF10A cells. Cell Invasion Assay [1] Cell Line: MDA-MB-231 Concentration: 5, 10 and 20 μM Incubation Time: 24 h Result: Significantly inhibited the invasion of MDA-MB-231 cells in a dose-dependent manner. Western Blot Analysis [1] Cell Line: MDA-MB-231 Concentration: 5, 10 and 20 μM Incubation Time: 72 h Result: Caused an obvious dose-dependent Y925 dephosphorylation of FAK. Apoptosis Analysis [1] Cell Line: MDA-MB-231 Concentration: 5, 10 and 20 μM Incubation Time: 72 h Result: Increased the percentage of apoptotic MDA-MB-231 cells ranging from 13.10% to 41.59% in a dose-dependent manner. |
分子量 | 334.41 |
分子式 | C20H22N4O |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
FAK-IN-4 Inhibitor inhibitor inhibit