Hu7691 free base is an orally active, potent and selective Akt inhibitor with anti-proliferative and neurogenic effects on a variety of neuroblastoma cell lines.Hu7691 free base inhibits Akt1, Akt2, and Akt3 and induces differentiation of neuroblastoma cells.

Akt2:97.5 nM (IC50), PKA:11 nM, Akt1:4.0 nM (IC50), AKT2:97.5 nM, AKT3:28 nM, RSK1:756 nM, RSK1:756 nM (IC50), PKA:11 nM (IC50), ROCK1:354 nM, mTOR (p70S6K):229 nM, AKT1:4.0 nM, PKCη:629 nM, PKCη:629 nM (IC50), Akt3:28 nM (IC50), p70 S6K:229 nM (IC50), ROCK1:354 nM (IC50)