Win-62005 competitively inhibits cyclic GMP-inhibitable low Km cyclic AMP phosphodiesterase (PDE III) from rat heart and canine aorta (Ki of 25±3 and 26±5 nM, respectively )and is selective (at least 160-fold) for PDE III inhibition relative to other PDE isozymes.

Win-62005(p.o. administration of 1 mg/kg) LVdP/dtmax is significantly increased in 30 min and remains increased for at least 6 h.