规格

价格

库存

数量

2 mg

¥ 497

现货

100 mg

¥ 9,581

6-8周

生物活性

产品描述	PF-06761281 (Compound 4a) is a potent and partially selective sodium-coupled citrate transporter protein (NaCT/SLC13A5) inhibitor with IC50 values of 0.51, 13.2, and 14.1 µM for NaCT, NaDC, and NaDC, respectively, and has the advantage of being orally active, reducing hepatic and renal uptake of citrate and plasma glucose concentration for metabolic diseases.
靶点活性	Selectivity over NaDC1/NaDC3:~13 μM, HEK293 cells:0.51 μM
体外活性	PF-06761281 是NaCT抑制剂，在HEK293细胞中IC₅₀为0.51 μM，在人、小鼠和大鼠肝细胞中IC₅₀分别为0.74、0.21和0.12 μM，对NaDC1/NaDC3选择性高（IC₅₀约13 μM）。水溶性24 mM（pH 6.5），渗透性低（P_app = 0.3×10⁻⁶ cm/s），肝细胞清除率<7 μL/min/10⁶ cells[1]。
别名	PF06761281

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

H2O: 40 mg/mL (141.2 mM), Sonication is recommended.

溶液配制表

H2O

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

PF-06761281