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Drofenine hydrochloride

Name: Drofenine hydrochloride
Brand: TargetMol
SKU: T0713
Price: 128 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.45%

货号 T0713Cas号 548-66-3

别名 盐酸六氢芬宁, Hexahydroadiphenine hydrochloride

Drofenine hydrochloride (Hexahydroadiphenine hydrochloride) 是竞争性胆碱酯酶抑制剂，ki=3 uM。

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Drofenine hydrochloride

一键复制产品信息

很棒

纯度: 99.45%

货号 T0713 别名 盐酸六氢芬宁, Hexahydroadiphenine hydrochlorideCas号 548-66-3

Drofenine hydrochloride (Hexahydroadiphenine hydrochloride) 是竞争性胆碱酯酶抑制剂，ki=3 uM。

规格	价格	库存
1 mg	¥ 128	现货
5 mg	¥ 256	现货
10 mg	¥ 358	现货
25 mg	¥ 579	现货
50 mg	¥ 756	现货
100 mg	¥ 1,080	现货
500 mg	¥ 2,760	现货
1 mL x 10 mM (in DMSO)	¥ 198	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.45%

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COA HNMR LCMS 产品操作手册

产品介绍

Drofenine hydrochloride AI Summary

Drofenine hydrochloride exhibits a diverse spectrum of bioactivities. It shows potency in numerous assays, including inhibiting ROR gamma transcriptional activity, activating and inhibiting Cytochrome P450 3A4, and delaying death induced by malarial parasite plastid inhibitors. It also inhibits TGF-b, Hepatitis C Virus, ATXN expression, human tyrosyl-DNA phosphodiesterase 1 (TDP1), and GLP-1 Receptor activity as an inverse agonist. Additionally, it induces synthetic lethality in tumor cells producing 2HG and interferes with the binding or entry of Marburg and Ebola viruses into cells. In SARS-CoV-2 related assays, Drofenine hydrochloride shows moderate activity in inhibiting the cell viability of infected Vero E6 cells, with an inhibition index of 0.499. It demonstrates 20.69% inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 µM after 48 hours and shows antiviral activity by inhibiting the 3CL-Pro protease by 9.639% at 20 µM. The compound also inhibits sodium fluorescein uptake significantly in OATP1B3 and OATP1B1-transfected CHO cells. Moreover, it has a minor effect on Vero E6 cells, inhibiting SARS-CoV-2 induced cytotoxicity by 0.33% at a concentration of 10 µM after 48 hours exposure to the virus..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Drofenine hydrochloride (Hexahydroadiphenine hydrochloride) is an effective competitive inhibitor of BChE (Ki value: 3 uM).
靶点活性	BChE:3 μM(ki)
别名	盐酸六氢芬宁, Hexahydroadiphenine hydrochloride

化学信息

分子量	353.93
分子式	C₂₀H₃₁NO₂·HCl
CAS No.	548-66-3
Smiles	Cl.CCN(CC)CCOC(=O)C(C1CCCCC1)c1ccccc1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 15 mg/mL (42.38 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.65 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8254 mL	14.1271 mL	28.2542 mL	141.2709 mL
5 mM	0.5651 mL	2.8254 mL	5.6508 mL	28.2542 mL
10 mM	0.2825 mL	1.4127 mL	2.8254 mL	14.1271 mL
20 mM	0.1413 mL	0.7064 mL	1.4127 mL	7.0635 mL