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Nomegestrol acetate

Name: Nomegestrol acetate
Brand: TargetMol
SKU: T8395
Price: 119 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 醋酸诺美孕酮

货号 T8395Cas号 58652-20-3 一键复制产品信息纯度: 99.91%

很棒

Nomegestrol acetate 是一种孕酮受体的完全激动剂，是一种高选择性孕激素。

Nomegestrol acetate

一键复制产品信息

很棒

纯度: 99.91%

货号 T8395Cas号 58652-20-3

别名 醋酸诺美孕酮

Nomegestrol acetate 是一种孕酮受体的完全激动剂，是一种高选择性孕激素。

为众多的药物研发团队赋能，

让新药发现更简单！

规格	价格	库存
1 mg	¥ 119	现货
5 mg	¥ 308	现货
10 mg	¥ 472	现货
25 mg	¥ 936	现货
50 mg	¥ 1,410	现货
100 mg	¥ 2,110	现货
200 mg	¥ 2,970	现货
1 mL x 10 mM (in DMSO)	¥ 259	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.91%

颜色: 白色

性状: Solid

资源下载: COA LCMS HNMR HPLC产品操作手册

产品介绍

Nomegestrol acetate AI Summary

Nomegestrol acetate exhibits a diverse range of bioactivities, showcasing its potential as an inhibitor in multiple biological contexts. It is potent in various assays targeting different biological activities, including Schistosoma Mansoni Peroxiredoxins, AmpC Beta-Lactamase, Nrf2, GCN5L2, Histone Lysine Methyltransferase G9a, delayed death inhibitors of the malarial parasite plastid, human tyrosyl-DNA phosphodiesterase 1 (TDP1), and as an antiviral against Foot and Mouth Disease Virus, with potency values ranging from 4610.9 nM to 100000.0 nM. Specifically, Nomegestrol acetate demonstrates antiviral activity against SARS-CoV-2. It showed moderate inhibition of cell viability in Vero E6 cells infected with SARS-CoV-2 after 72 hours of treatment, exhibiting an inhibition index of 0.6186. It also inhibited SARS-CoV-2 induced cytotoxicity by 14.66% in Caco-2 cells at a concentration of 10 µM after 48 hours. Additionally, in HRCE cells, the compound exhibited antiviral activity against the SARS-CoV-2 (USA-WA1/2020 strain) with a hit score of 0.2782 at MOI 0.4 after 96 hours. Despite these activities, its inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM was moderate, with an inhibition percentage of 11.84%. The compound was also active in VERO-6 cells with an IC50 greater than 20000.0 nM, indicating a relatively high concentration required for a significant inhibitory effect. Furthermore, Nomegestrol acetate showed inhibition in enzymatic assays of human HDAC6 using different peptide substrates, with inhibition percentages of 41.31% and 1.72%. It also demonstrated high binding affinity towards numerous receptors and transporters in in vitro assays, with significant activities noted: - Inhibition of rat Gabra1 with an AC50 of 2500.0 nM. - High affinity binding to human PGR and AR with AC50 values of 3.0 nM and 20.0 nM, respectively. - Moderate inhibition of human PDE4D with an AC50 of 14000.1 nM. - Inhibition of human NR3C1 with an AC50 of 67.0 nM. In summary, Nomegestrol acetate is a multi-target agent with noteworthy inhibitory and antiviral properties, making it a candidate for further investigation in various biological and therapeutic contexts..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Nomegestrol acetate is a widely used progestin-like drug,which is characterized as a full agonist at the progesterone receptor
别名	醋酸诺美孕酮

化学信息

分子量	370.48
分子式	C₂₃H₃₀O₄
CAS No.	58652-20-3
Smiles	[H][C@@]12CC[C@](OC(C)=O)(C(C)=O)[C@@]1(C)CC[C@]1([H])[C@@]3([H])CCC(=O)C=C3C(C)=C[C@@]21[H]
密度	1.16 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 62.5 mg/mL (168.7 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.4 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6992 mL	13.4960 mL	26.9920 mL	134.9601 mL
5 mM	0.5398 mL	2.6992 mL	5.3984 mL	26.9920 mL
10 mM	0.2699 mL	1.3496 mL	2.6992 mL	13.4960 mL
20 mM	0.1350 mL	0.6748 mL	1.3496 mL	6.7480 mL
50 mM	0.0540 mL	0.2699 mL	0.5398 mL	2.6992 mL
100 mM	0.0270 mL	0.1350 mL	0.2699 mL	1.3496 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。