BChE-IN-17 (compound 6n) is a potent, selective inhibitor of butyrylcholinesterase (BChE), demonstrating inhibitory half-maximal inhibitory concentrations (IC50s) of 10.5 nM for equine BChE (eqBChE) and 32.5 nM for human BChE (hBChE). It exhibits over 1000-fold greater selectivity for BChE compared to acetylcholinesterase (AChE), while also presenting low neurotoxicity and moderate neuroprotective effects [1].

eqBCHE:10.5 nM, BCHE (human):32.5 nM, AChE:686.4 μM