Bleomycin hydrochloride

规格	价格/CNY		货期
1 mg	￥ 287	现货
5 mg	￥ 672	现货
10 mg	￥ 1,080	现货
50 mg	特惠询价		现货

规格

价格/CNY

货期

数量

1 mg

￥ 287

现货

5 mg

￥ 672

现货

10 mg

￥ 1,080

现货

50 mg

特惠询价

现货

存储

store at low temperature　|　Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 45 mg/mL (31 mM), Sonication and heating to 60℃ are recommended.

H2O: 80 mg/mL (55.13 mM), Sonication is recommended.

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO / H2O	1 mM	0.6892 mL	3.4459 mL	6.8918 mL	17.2294 mL
	5 mM	0.1378 mL	0.6892 mL	1.3784 mL	3.4459 mL
	10 mM	0.0689 mL	0.3446 mL	0.6892 mL	1.7229 mL
	20 mM	0.0345 mL	0.1723 mL	0.3446 mL	0.8615 mL
H2O	50 mM	0.0138 mL	0.0689 mL	0.1378 mL	0.3446 mL

产品描述	Bleomycin hydrochloride is a potent antitumor antibiotic that functions as a DNA synthesis inhibitor and DNA damaging agent.
体外活性	Bleomycin hydrochloride is chosen as the best-studied micronucleus inducers in human lymphocytes with different mechanisms of genotoxicity. The most frequent Bleomycin-induced DNA lesions are single and double strand breaks and single apuinic/apyrimidinic sites. At the same time Bleomycin is true radiomimetic compound, resembling almost completely the genetic effect of ionizing radiation[1]. The IC50 value of Bleomycin hydrochloride for UT-SCC-19A cell line is 4.0±1.3 nM. UT-SCC-12A and UT-SCC-12B are both more resistant to Bleomycin; IC50 values are 14.2±2.8 nM and 13.0±1.1 nM, respectively[2]. Bleomycin hydrochloride (50, 100 μM; for 24, 48 h) induce pulmonary fibrosis in RLE-6TN cell (50 μM) and A549 cell (100 μM)[4].
体内活性	Bleomycin hydrochloride treatment (3.5-4.0 mg/kg; intra-tracheal) on day 0, body weights decreases by day 4 then increases by Day 7 through the end of the study[3]. Bleomycin hydrochloride (3.5-4.0 mg/kg; intra-tracheal) produces a statistically significant increase in lung hydroxyproline levels, and also increases right caudal lung lobe mass[3]. Bleomycin hydrochloride (intratracheal instillation; 5.0 mg/kg/day) induces pulmonary fibrosis in eighty 8-week-old male BALB/c mice with weight about 20-30 g. Bleomycin induces the expression levels of α-SMA and collagen I[4]. Bleomycin hydrochloride (intratracheally; 2.5 mg/kg; 1.25 mg/ml, approximately 50 µl per mouse) induces pulmonary fibrosis in male C57BL/6 mice (8 weeks old, average weight approximately 24.5 g)[5].

分子量	1451.01
分子式	C55H84ClN17O21S3
CAS No.	67763-87-5

存储

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溶液配制表

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