Name: S65487 sulfate
Brand: TargetMol
SKU: T40070
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

待询

6-8周

50 mg

待询

6-8周

100 mg

待询

6-8周

生物活性

产品描述	S65487 (VOB560) sulfate, a potent and selective Bcl-2 inhibitor, demonstrates activity against BCL-2 mutations, including G101V and D103Y. It exhibits poor affinity for MCL-1, BFL-1, and BCL-XL. Additionally, S65487 sulfate induces apoptosis and possesses anticancer activities.
体外活性	S65487 binds to the BH3 hydrophobic groove of BCL-2. S65487 induces apoptosis in a panel of hematological cancer cell lines and inhibits cell proliferation with IC 50 s in the low nM range[1].
体内活性	S65487 induces complete regression in BCL-2-dependent RS4;11 tumors in vivo after a single IV (intravenous) administration. Strong and persistent tumor regression in xenograft models of lymphoid malignancies in mouse and rat are observed at well tolerated doses following weekly IV administration of S65487 in combination with the MCL-1-specific inhibitor, S64315/MIK665[1].
别名	VOB560 sulfate

化学信息

分子量	815.34
分子式	C₄₁H₄₃ClN₆O₈S
CAS No.	2416937-01-2
Smiles	OS(O)(=O)=O.Cc1c(cc(C#N)n1C)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1
密度	no data available

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

S65487 sulfate