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Hydroxychloroquine

Name: Hydroxychloroquine
Brand: TargetMol
SKU: T9287
Price: 136 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.79%

货号 T9287Cas号 118-42-3

别名 羟氯喹, 2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol

Hydroxychloroquine (2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol) 是一种合成抗疟疾剂，有效抑制SARS-CoV-2感染，也抑制 Toll 样受体 7/9 信号传导。

Hydroxychloroquine

一键复制产品信息

很棒

纯度: 99.79%

货号 T9287 别名 羟氯喹, 2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanolCas号 118-42-3

Hydroxychloroquine (2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol) 是一种合成抗疟疾剂，有效抑制SARS-CoV-2感染，也抑制 Toll 样受体 7/9 信号传导。

规格	价格	库存
10 mg	¥ 136	现货
25 mg	¥ 198	现货
50 mg	¥ 289	现货
100 mg	¥ 413	现货
200 mg	¥ 619	现货
500 mg	¥ 955	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.79%

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资源下载:

COA HNMR LCMS HPLC 产品操作手册

产品介绍

生物活性

产品描述	Hydroxychloroquine (2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol) (HCQ) is an alkalinizing lysosomatropic drug that acts by inducing apoptosis of renal cancer cells in vitro and inhibiting TLR7/9. It is a medication used to prevent and treat malaria, and it's also being studied as an experimental treatment for COVID-19.
别名	羟氯喹, 2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol

化学信息

分子量	335.87
分子式	C₁₈H₂₆ClN₃O
CAS No.	118-42-3
Smiles	CCN(CCO)CCCC(C)NC1=CC=NC2=CC(Cl)=CC=C12
密度	1.176 g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 1.65 mg/mL (4.91 mM), Sonication and heating to 60℃ are recommended.

DMSO: 257 mg/mL (765.18 mM), Sonication is recommended.

1M HCl: 99 mg/mL (294.76 mM), when pH is adjusted to 2 with HCl.

溶液配制表

H2O/1M HCl/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9773 mL	14.8867 mL	29.7734 mL	148.8671 mL

1M HCl/DMSO

	1mg	5mg	10mg	50mg
5 mM	0.5955 mL	2.9773 mL	5.9547 mL	29.7734 mL
10 mM	0.2977 mL	1.4887 mL	2.9773 mL	14.8867 mL
20 mM	0.1489 mL	0.7443 mL	1.4887 mL	7.4434 mL
50 mM	0.0595 mL	0.2977 mL	0.5955 mL	2.9773 mL
100 mM	0.0298 mL	0.1489 mL	0.2977 mL	1.4887 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

TargetMol AI Summary

Hydroxychloroquine exhibits multifaceted bioactivities and pharmacokinetic properties. It is a modulator of Lamin A splicing with a potency of 35481.3 nM and acts as a delayed-death inhibitor of malaria parasite plastid with potencies of 169.4 nM and 151.0 nM after 96-hour and 48-hour incubations, respectively. The compound shows antiviral activities against SARS-CoV-2 and Dengue virus 2, with significant potency in inhibiting viral replication in Vero E6 and BHK-21 cells. It also inhibits SARS-CoV-2 3CL-Pro protease and Zika virus NS2B-NS3 protease. Moreover, Hydroxychloroquine has antagonistic effects on TLR7 and TLR9, and demonstrates cytotoxicity against various cell lines, including African green monkey Vero cells and human A549 cells. Pharmacokinetically, Hydroxychloroquine showcases a large volume of distribution (Vdss = 700.0 L.kg-1), a long half-life (T1/2 = 850.0 hr), and a mean residence time (MRT = 1300.0 hr). It has moderate plasma protein binding (Fu = 0.57) and a clearance rate of 11.0 mL.min-1.kg-1. Upon oral administration, it reaches Tmax in 2.4 hours with a Cmax of 1220.0 nM and an AUC value of 34360.52 ng.hr.mL-1. The compound exhibits moderate to severe hepatic side effects, such as hepatic failure with a high HepSE score and moderate liver toxicity during clinical trials. In terms of receptor binding, Hydroxychloroquine shows affinity for Alpha-1D adrenergic, Imidazoline I2, Muscarinic M2 receptors, and others, with varying IC50 values. Additionally, it has shown bioactivity in inhibiting human recombinant ACE2 and cGAS in THP-1 cells, with potent inhibitory effects on certain receptors, transporters, and enzymes. Overall, Hydroxychloroquine possesses diverse bioactivities across different biological targets and demonstrates significant pharmacokinetic and toxicological profiles, indicating its potential for various therapeutic applications and the necessity for cautious consideration of its side effect profile..

Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl