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Canrenoate potassium

Name: Canrenoate potassium
Brand: TargetMol
SKU: T3096
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 坎利酸钾, Soldactone, Potassium canrenoate, Potassium aldadiene, Canrenoic acid potassium salt

货号 T3096Cas号 2181-04-6 一键复制产品信息纯度: 99.18%

很棒

Canrenoate potassium (Soldactone) 是一种有效的竞争性盐皮质激素受体 (mineralocorticoid receptor) 拮抗剂，是一种释放 canrenone 的前药。它作为一种利尿剂，用于高血压的研究。

Canrenoate potassium

一键复制产品信息

很棒

纯度: 99.18%

货号 T3096Cas号 2181-04-6

别名 坎利酸钾, Soldactone, Potassium canrenoate, Potassium aldadiene, Canrenoic acid potassium salt

规格	价格	库存	数量
50 mg	¥ 99	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.18%

颜色: 白色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

Canrenoate potassium AI Summary

Canrenoate potassium demonstrates a variety of bioactivities across multiple assays. It acts as an inhibitor of AmpC Beta-Lactamase with a potency of 3162.3 nM. In human cellular assays, it inhibits tyrosyl-DNA phosphodiesterase 1 (TDP1) with varying potencies: 14319.4 nM and 4109.5 nM without camptothecin (CPT), and 12762.2 nM with CPT. The compound also inhibits AMA1-RON for antimalarial drug development with a potency of 22387.2 nM. In terms of transporter activity, Canrenoate potassium inhibits sodium fluorescein uptake in OATP1B1-transfected CHO cells with a 76.46% inhibition and in OATP1B3-transfected CHO cells with 69.66% inhibition at 10 µM concentration. Regarding its antiviral properties, the compound shows low activity in inhibiting cell viability in Vero E6 cells infected with SARS-CoV-2, with an inhibition index of 0.2042. It exhibits some activity against SARS-CoV-2 by reducing induced cytotoxicity in Caco-2 cells (-3.42% inhibition) and Vero-6 cells (-0.09% inhibition) at 10 µM concentration. Additionally, it inhibits SARS-CoV-2 3CL-Pro protease by 14.07% at 20 µM concentration, as measured by FRET-based assays. Furthermore, Canrenoate potassium displays a broad range of binding affinities and activities across various receptors and enzymes but does not exhibit significant bioactivity in terms of inhibition or agonist activity at the evaluated concentrations (AC50 > 30000.0 nM)..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Canrenoate potassium (Soldactone) is a synthetic pregnadiene derivative with anti-aldosterone activity.
别名	坎利酸钾, Soldactone, Potassium canrenoate, Potassium aldadiene, Canrenoic acid potassium salt

化学信息

分子量	396.56
分子式	C₂₂H₂₉KO₄
CAS No.	2181-04-6
Smiles	[K+].C(=O)(CC[C@@]1(CC[C@H]2[C@@H]3C=CC4=CC(=O)CC[C@@]4([C@H]3CC[C@]12C)C)O)[O-]
密度	1.345 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: Slightly soluble

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

SC-14266 SC14266 SC 14266 Mineralocorticoid Receptor Inhibitor inhibit hypertension GlucocorticoidReceptor Glucocorticoid Receptor fibrosis diuretic competitive cardiac Canrenoic acid potassium Canrenoate potassium Canrenoate Aldadiene

Canrenoate potassium

Canrenoate potassium