Canrenoate potassium

Name: Canrenoate potassium
Brand: TargetMol
SKU: T3096
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.18%

货号 T3096Cas号 2181-04-6

别名 坎利酸钾, Soldactone, Potassium canrenoate, Potassium aldadiene, Canrenoic acid potassium salt

Canrenoate potassium (Soldactone) 是一种有效的竞争性盐皮质激素受体 (mineralocorticoid receptor) 拮抗剂，是一种释放 canrenone 的前药。它作为一种利尿剂，用于高血压的研究。

Canrenoate potassium

一键复制产品信息

很棒

纯度: 99.18%

货号 T3096 别名 坎利酸钾, Soldactone, Potassium canrenoate, Potassium aldadiene, Canrenoic acid potassium saltCas号 2181-04-6

规格	价格	库存	数量
50 mg	¥ 99	现货

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纯度: 99.18%

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COA HNMR LCMS 产品操作手册

产品介绍

Canrenoate potassium AI Summary

Canrenoate potassium demonstrates a variety of bioactivities across multiple assays. It acts as an inhibitor of AmpC Beta-Lactamase with a potency of 3162.3 nM. In human cellular assays, it inhibits tyrosyl-DNA phosphodiesterase 1 (TDP1) with varying potencies: 14319.4 nM and 4109.5 nM without camptothecin (CPT), and 12762.2 nM with CPT. The compound also inhibits AMA1-RON for antimalarial drug development with a potency of 22387.2 nM. In terms of transporter activity, Canrenoate potassium inhibits sodium fluorescein uptake in OATP1B1-transfected CHO cells with a 76.46% inhibition and in OATP1B3-transfected CHO cells with 69.66% inhibition at 10 µM concentration. Regarding its antiviral properties, the compound shows low activity in inhibiting cell viability in Vero E6 cells infected with SARS-CoV-2, with an inhibition index of 0.2042. It exhibits some activity against SARS-CoV-2 by reducing induced cytotoxicity in Caco-2 cells (-3.42% inhibition) and Vero-6 cells (-0.09% inhibition) at 10 µM concentration. Additionally, it inhibits SARS-CoV-2 3CL-Pro protease by 14.07% at 20 µM concentration, as measured by FRET-based assays. Furthermore, Canrenoate potassium displays a broad range of binding affinities and activities across various receptors and enzymes but does not exhibit significant bioactivity in terms of inhibition or agonist activity at the evaluated concentrations (AC50 > 30000.0 nM)..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Canrenoate potassium (Soldactone) is a synthetic pregnadiene derivative with anti-aldosterone activity.
别名	坎利酸钾, Soldactone, Potassium canrenoate, Potassium aldadiene, Canrenoic acid potassium salt

化学信息

分子量	396.56
分子式	C₂₂H₂₉KO₄
CAS No.	2181-04-6
Smiles	[K+].C(=O)(CC[C@@]1(CC[C@H]2[C@@H]3C=CC4=CC(=O)CC[C@@]4([C@H]3CC[C@]12C)C)O)[O-]
密度	1.345 g/cm3

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度信息	DMSO: Slightly soluble