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Econazole

Name: Econazole
Brand: TargetMol
SKU: T0444
Price: 153 CNY
Availability: InStock
Rating: 5 (10 reviews)

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货号 T0444Cas号 27220-47-9

别名 益康唑, (±)-Econazol

Econazole ((±)-Econazol) 是一种咪唑衍生物，是一种抗真菌剂。

Econazole

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很棒

纯度: 99.97%

货号 T0444 别名 益康唑, (±)-EconazolCas号 27220-47-9

Econazole ((±)-Econazol) 是一种咪唑衍生物，是一种抗真菌剂。

规格	价格	库存
100 mg	¥ 153	现货
500 mg	¥ 328	现货
1 mL x 10 mM (in DMSO)	¥ 363	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

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资源下载:

COA LCMS HNMR HPLC 产品操作手册

产品介绍

生物活性

产品描述	Econazole ((±)-Econazol) is an imidazole derivative that is commonly used as a topical antifungal agent.
别名	益康唑, (±)-Econazol

化学信息

分子量	381.68
分子式	C₁₈H₁₅Cl₃N₂O
CAS No.	27220-47-9
Smiles	C(CN1C=CN=C1)(OCC2=CC=C(Cl)C=C2)C3=C(Cl)C=C(Cl)C=C3
密度	1.33 g/cm3 (Predicted)

储存&溶解度

存储

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 250 mg/mL (655 mM), Sonication is recommended.

Ethanol: 5 mg/mL (13.1 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

体内实验配方

10% DMSO+90% Saline: 2.5 mg/mL (6.55 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6200 mL	13.1000 mL	26.2000 mL	130.9998 mL
5 mM	0.5240 mL	2.6200 mL	5.2400 mL	26.2000 mL
10 mM	0.2620 mL	1.3100 mL	2.6200 mL	13.1000 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1310 mL	0.6550 mL	1.3100 mL	6.5500 mL
50 mM	0.0524 mL	0.2620 mL	0.5240 mL	2.6200 mL
100 mM	0.0262 mL	0.1310 mL	0.2620 mL	1.3100 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

TargetMol AI Summary

Econazole exhibits a diverse spectrum of bioactivities across various biological targets. It shows notable antifungal activity against strains such as Candida albicans, Aspergillus fumigatus, and Trichophyton asteroides with respective MIC values of 3.1 µg/mL, 3.1 µg/mL, and 0.1 µg/mL. It also targets sterol 14-alpha-demethylase with a concentration of 26.0 µM, indicating its fungicidal action, alongside inhibiting beta-lactamase and several other enzymes such as chymotrypsinogen and malate dehydrogenase. Econazole demonstrates inhibition of human Cytochrome P450 17A1 with a Ki of 325.0 nM and has notable activities against Candida parapsilosis and dermatophytes with a MIC range of 1.0 to 8.0 µg/mL. The compound exhibits antitubercular effects against Mycobacterium tuberculosis H37Rv with a MIC of 12.5 µg/mL and possesses antibacterial activity against Nocardia brasiliensis. It also affects human liver enzymes, suggesting a potential for hepatotoxicity and shows antiviral properties against SARS-CoV-2. In addition to its antifungal and antibacterial properties, Econazole has shown inhibition of several CYP450 enzymes (with an IC50 of 430.53 nM for CYP3A4) and exhibits antitumor activities with varying GI50 values across multiple human tumor cell lines. It has effects on biochemical parameters related to liver and kidney functions and demonstrates various receptor binding affinities, including activity against TRPM2, TRPM8, and HDAC6. Overall, Econazole displays a wide array of bioactivities, indicating its potential as a multi-target pharmaceutical agent, but careful consideration of its cytotoxic and enzyme-inhibitory properties is required..

Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl